Protein arginine methyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:30163]
Entrez Summary
This gene belongs to the protein arginine methyltransferase (PRMT)
family. The encoded enzyme catalyzes the methylation of guanidino nitrogens
of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2
(rpS2), which is its major in-vivo substrate, and is involved in the proper
maturation of the 80S ribosome. Alternative splicing results in multiple
transcript variants. [provided by RefSeq, Aug 2013]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
x
CisBP considers it as a TF?
No
TFclass considers it as a TF?
No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF