TF Info Page for ZBTB7C (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: zinc finger and BTB domain containing 7C [Source:HGNC Symbol;Acc:HGNC:31700]
Entrez Summary NA
Ensembl ID: ENSG00000184828
External Link: CisBP
Interpro IPR000210; IPR007087; IPR011333; IPR013069; IPR015880; IPR016024;
Protein Domain: ENSP00000439781
Protein Domain: ENSP00000464724
Protein Domain: ENSP00000466944
Protein Domain: ENSP00000468254
Protein Domain: ENSP00000468537
Protein Domain: ENSP00000466006
Protein Domain: ENSP00000465760
Protein Domain: ENSP00000468152
Protein Domain: ENSP00000466088
Protein Domain: ENSP00000468814
Protein Domain: ENSP00000467456
Protein Domain: ENSP00000468502
Protein Domain: ENSP00000468782
Protein Domain: ENSP00000467147
Protein Domain: ENSP00000467338
Protein Domain: ENSP00000468019
Protein Domain: ENSP00000465160
Protein Domain: ENSP00000465494
Protein Domain: ENSP00000467323
Protein Domain: ENSP00000467877
Protein Domain: ENSP00000468306
Protein Domain: ENSP00000465265
Protein Domain: ENSP00000467758
Protein Domain: ENSP00000468752
Protein Domain: ENSP00000465835
Protein Domain: ENSP00000468087
Protein Domain: ENSP00000465832
Domain:
Protein: ENSP00000439781DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000464724DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000466944DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000468254DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000468537DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000466006DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000465760DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000468152DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000466088DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000468814DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000467456DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000468502DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000468782DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000467147DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000467338DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000468019DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000465160DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000465494DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000467323DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000467877DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000468306DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000465265DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000467758DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000468752DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000465835DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000468087DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000465832DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
TransfacTransfacLicense requiredDirect
HT-SELEXYin2017Inferred - ZBTB7A (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ZBTB7A (75% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - ZBTB7A (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ZBTB7A (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ZBTB7A (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ZBTB7A (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ZBTB7A (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ZBTB7A (75% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ZBTB7A (75% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution