TF Info Page for POU6F1 (Homeodomain; POU)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: POU class 6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:9224]
Entrez Summary NA
Ensembl ID: ENSG00000184271
External Link: CisBP
Interpro IPR000327; IPR001356; IPR009057; IPR010982; IPR013847; ;
Protein Domain: ENSP00000330190
Protein Domain: ENSP00000448389
Protein Domain: ENSP00000373895
Protein Domain: ENSP00000490559
Protein: ENSP00000330190DBD: Homeodomain,POUOther:
Protein: ENSP00000448389DBD: Homeodomain,POUOther:
Protein: ENSP00000373895DBD: Homeodomain,POUOther:
Protein: ENSP00000490559DBD: Homeodomain,POUOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000002
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
PBMBerger08Inferred - Pou6f1 (99% AA Identity, Mus musculus)
PBMBerger08Inferred - Pou6f1 (99% AA Identity, Mus musculus)
PBMZoo_01Inferred - pdm3 (68% AA Identity, Drosophila melanogaster)


Structure PDB 3D1N

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution