TF Info Page for NKX2-5 (Homeodomain)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | NK2 homeobox 5 [Source:HGNC Symbol;Acc:HGNC:2488] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000183072 | |
| External Link: | ||
| Interpro | IPR001356; IPR009057; IPR017970; IPR020479; | |
| Protein Domain: | ||
| Protein: ENSP00000327758 | DBD: Homeodomain | Other: |
| Protein: ENSP00000395378 | DBD: Homeodomain | Other: |
| Protein: ENSP00000427906 | DBD: Homeodomain | Other: |
| Protein: ENSP00000429905 | DBD: Homeodomain | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding TF PPI Transactivation_ PMIDS:9584181 10318839 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IMP - PMID:15649947 GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor IDA - PMID:19578358 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:10948187, PMID:11431700, PMID:9312027, GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000019 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |