TF Info Page for SATB1 (CUT; Homeodomain)


Assessment Binding Mode Motif Status Notes Comments
Known motif 3 Low specificity DNA-binding protein In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain SATBs were analyzed by Gwenael Badis and Mike Berger a decade ago; by PBMs. It did not yield a motif; instead; the signal was very closely proportional to nucleotide content, as the name suggests (Special AT Binding).


Description: SATB homeobox 1 [Source:HGNC Symbol;Acc:HGNC:10541]
Entrez Summary This gene encodes a matrix protein which binds nuclear matrix and scaffold-associating DNAs through a unique nuclear architecture. The protein recruits chromatin-remodeling factors in order to regulate chromatin structure and gene expression. [provided by RefSeq, Apr 2016]
Ensembl ID: ENSG00000182568
External Link: CisBP
Interpro IPR001356; IPR003350; IPR009057; IPR010982;
Protein Domain: ENSP00000341024
Protein Domain: ENSP00000399518
Protein Domain: ENSP00000399708
Protein Domain: ENSP00000479866
Protein Domain: ENSP00000408871
Protein Domain: ENSP00000390529
Protein Domain: ENSP00000453908
Protein: ENSP00000341024DBD: CUT, HomeodomainOther: CUTL, ULD
Protein: ENSP00000399518DBD: CUT, HomeodomainOther: CUTL, SUIM_assoc, ULD
Protein: ENSP00000399708DBD: CUT, HomeodomainOther: CUTL, ULD
Protein: ENSP00000479866DBD: CUT, HomeodomainOther: CUTL, RuvA_C, ULD
Protein: ENSP00000408871DBD: CUT, HomeodomainOther: ULD
Protein: ENSP00000390529DBD: CUT, HomeodomainOther: ULD
Protein: ENSP00000453908DBD: CUT, HomeodomainOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:1505028 8114718 9340009
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001227
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IDA - PMID:15851481
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect


Structure PDB 2O49

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution