Conclusion
Assessment
Binding Mode
Motif Status
Notes
Comments
Known motif
1 Monomer or homomultimer
100 perc ID - in vitro
Description
Description:
cAMP responsive element binding protein 3 like 2 [Source:HGNC Symbol;Acc:HGNC:23720]
Entrez Summary
NA
Ensembl ID:
ENSG00000182158
External Link:
CisBP
Interpro
IPR004827 ; ;
Protein Domain:
ENSP00000329140
Protein Domain:
ENSP00000410314
Protein Domain:
ENSP00000403550
Protein Domain:
ENSP00000402889
Protein Domain:
ENSP00000388917
Domain:
Protein: ENSP00000329140DBD: bZIPOther: Protein: ENSP00000410314DBD: bZIPOther: Protein: ENSP00000403550DBD: bZIPOther: Protein: ENSP00000402889DBD: bZIPOther: Protein: ENSP00000388917DBD: bZIPOther:
Previous Annotations
Source
Annotation
TF-CAT classification
No PMIDS:
Vaquerizas 2009 TF classification
"a " Has direct evidence of TF function;
"b " Has evidence for an orthologous TF;
"c " contains likely DBDs, but has no functional evidence;
"x " is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other " category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements
DNA-Binding
Published Motif Data
Structure
Experimental History
{"regions": [{"startStyle": "curved", "end": 355, "endStyle": "curved", "aliStart": 292, "text": "bZIP", "colour": "#009900", "aliEnd": 354, "start": 292, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 355, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 292, "scoreName": "E-value", "accession": "PF00170.19", "start": 292, "score": 1.7e-14, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 354}}, {"startStyle": "jagged", "end": 358, "endStyle": "curved", "aliStart": 287, "text": "MAF", "colour": "#FFD800", "aliEnd": 358, "start": 285, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 358, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 287, "scoreName": "E-value", "accession": "PF03131.15", "start": 285, "score": 1.8000000000000001e-06, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 358}}], "length": 521}
{"regions": [{"startStyle": "curved", "end": 355, "endStyle": "curved", "aliStart": 292, "text": "bZIP", "colour": "#009900", "aliEnd": 354, "start": 292, "href": "http://pfam.xfam.org/family/PF00170.19", "type": "pfama", "display": "true", "metadata": {"end": 355, "description": "The Pfam entry includes the basic region and the leucine zipper region.", "database": "PfamA", "aliStart": 292, "scoreName": "E-value", "accession": "PF00170.19", "start": 292, "score": 1.5999999999999998e-14, "identifier": "bZIP transcription factor", "type": "DBD", "aliEnd": 354}}, {"startStyle": "jagged", "end": 358, "endStyle": "curved", "aliStart": 287, "text": "MAF", "colour": "#FFD800", "aliEnd": 358, "start": 285, "href": "http://pfam.xfam.org/family/PF03131.15", "type": "pfama", "display": "true", "metadata": {"end": 358, "description": "Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerisation and DNA binding property [1]. Thus, this family is probably related to Pfam:PF00170. This family also includes the DNA_binding domain of Skn-1 (Swiss:P34707), this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer [2,3].", "database": "PfamA", "aliStart": 287, "scoreName": "E-value", "accession": "PF03131.15", "start": 285, "score": 1.8000000000000001e-06, "identifier": "bZIP Maf transcription factor", "type": "DBD", "aliEnd": 358}}], "length": 461}