TF Info Page for CREB3L2 (bZIP)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer 100 perc ID - in vitro

Description

Description: cAMP responsive element binding protein 3 like 2 [Source:HGNC Symbol;Acc:HGNC:23720]
Entrez Summary This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Ensembl ID: ENSG00000182158
External Link: CisBP
Interpro IPR004827; ;
Protein Domain: ENSP00000329140
Protein Domain: ENSP00000410314
Protein Domain: ENSP00000403550
Protein Domain: ENSP00000402889
Protein Domain: ENSP00000388917
Domain:
Protein: ENSP00000329140DBD: bZIPOther:
Protein: ENSP00000410314DBD: bZIPOther:
Protein: ENSP00000403550DBD: bZIPOther:
Protein: ENSP00000402889DBD: bZIPOther:
Protein: ENSP00000388917DBD: bZIPOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMZoo_01Inferred - Creb3l2 (100% AA Identity, Mus musculus)
PBMTF_EvolutionUnpublished DataInferred - CREB3L2 (95% AA Identity, Monodelphis domestica)
HT-SELEXNitta2015Inferred - CrebA (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CrebA (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CrebA (70% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - CREB3L1 (67% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution