TF Info Page for ZBTB20 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: zinc finger and BTB domain containing 20 [Source:HGNC Symbol;Acc:HGNC:13503]
Entrez Summary This gene, which was initially designated as dendritic cell-derived BTB/POZ zinc finger (DPZF), belongs to a family of transcription factors with an N-terminal BTB/POZ domain and a C-terminal DNA-bindng zinc finger domain. The BTB/POZ domain is a hydrophobic region of approximately 120 aa which mediates association with other BTB/POZ domain-containing proteins. This gene acts as a transcriptional repressor and plays a role in many processes including neurogenesis, glucose homeostasis, and postnatal growth. Mutations in this gene have been associated with Primrose syndrome as well as the 3q13.31 microdeletion syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017]
Ensembl ID: ENSG00000181722
External Link: CisBP
Interpro IPR000210; IPR007087; IPR011333; IPR013069; IPR015880; ;
Protein Domain: ENSP00000349803
Protein Domain: ENSP00000377375
Protein Domain: ENSP00000420324
Protein Domain: ENSP00000417307
Protein Domain: ENSP00000419902
Protein Domain: ENSP00000419153
Protein Domain: ENSP00000418092
Domain:
Protein: ENSP00000349803DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000377375DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000420324DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000417307DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000419902DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000419153DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000418092DBD: C2H2 ZF Containing ProteinsOther: BTB

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:11744704
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution