TF Info Page for ATOH7 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: atonal bHLH transcription factor 7 [Source:HGNC Symbol;Acc:HGNC:13907]
Entrez Summary This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment. [provided by RefSeq, Dec 2011]
Ensembl ID: ENSG00000179774
External Link: CisBP
Interpro IPR011598; ;
Protein Domain: ENSP00000362777
Domain:
Protein: ENSP00000362777DBD: bHLHOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate__Transactivation_
PMIDS:7721778 15882586 17653051
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
HT-SELEXYin2017Inferred - ATOH1 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ATOH1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH1 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH1 (75% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Atoh1 (75% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ATOH1 (75% AA Identity, Homo sapiens)
SELEXJASPARInferred - Atoh1 (75% AA Identity, Mus musculus)
MiscHOMERInferred - Atoh1 (75% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - amos (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - amos (71% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - NEUROD1 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROD1 (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NEUROD1 (59% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NEUROD1 (59% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NEUROD1 (59% AA Identity, Homo sapiens)
MiscHOMERInferred - Neurod1 (59% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - BHLHA15 (57% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - BHLHA15 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHA15 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHA15 (57% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Bhlha15 (57% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - NEUROD2 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROD2 (57% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROG2 (56% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROG2 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG2 (56% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG2 (56% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROG1 (52% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROG1 (52% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG1 (52% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG1 (52% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Neurog1 (52% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - dimm (51% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - dimm (51% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - FERD3L (51% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FERD3L (51% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FERD3L (51% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FERD3L (51% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - Fer1 (50% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - HAND2 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HAND2 (50% AA Identity, Homo sapiens)
PBMGrove09Inferred - hlh-10 (50% AA Identity, Caenorhabditis elegans)
HT-SELEXYin2017Inferred - MSC (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MSC (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MSC (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - MSC (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - MSC (50% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Msc (50% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - TCF21 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - TCF21 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TCF21 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - TCF21 (50% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Tcf21 (50% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution