TF Info Page for ZBTB42 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro ChIP-seq motif is consistent with recognition code (RCADE)

Description

Description: zinc finger and BTB domain containing 42 [Source:HGNC Symbol;Acc:HGNC:32550]
Entrez Summary The protein encoded by this gene is a member of the C2H2 zinc finger protein family. This protein is predicted to have a pox virus and zinc finger (POZ) domain at the N-terminus and four zinc finger domains at the C-terminus. In human and mouse, the protein localizes to the nuclei of skeletal muscle cells. Knockdown of this gene in zebrafish results in abnormal skeletal muscle development and myofibrillar disorganization. A novel homozygous variant of the human gene has been associated with lethal congenital contracture syndrome, an autosomal recessive disorder that results in muscle wasting. [provided by RefSeq, Mar 2015]
Ensembl ID: ENSG00000179627
External Link: CisBP
Interpro IPR000210; IPR007087; IPR011333; IPR013069; IPR015880; ;
Protein Domain: ENSP00000450673
Protein Domain: ENSP00000409107
Domain:
Protein: ENSP00000450673DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000409107DBD: C2H2 ZF Containing ProteinsOther: BTB

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
No
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
RCADESchmitges2016Direct
HT-SELEXYin2017Inferred - ZBTB18 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ZBTB18 (82% AA Identity, Homo sapiens)
ChIP-seqNajafabadi2015Inferred - ZBTB18 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ZBTB18 (82% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ZBTB18 (82% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ZBTB18 (82% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution