TF Info Page for EGR3 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: early growth response 3 [Source:HGNC Symbol;Acc:HGNC:3240]
Entrez Summary This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]
Ensembl ID: ENSG00000179388
External Link: CisBP
Interpro IPR007087; IPR015880; IPR021849; ;
Protein Domain: ENSP00000318057
Protein Domain: ENSP00000430310
Protein Domain: ENSP00000429370
Domain:
Protein: ENSP00000318057DBD: C2H2 ZF Containing ProteinsOther: DUF3446
Protein: ENSP00000430310DBD: C2H2 ZF Containing ProteinsOther: DUF3446
Protein: ENSP00000429370DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene Candidate_DNA-Binding
sequence-specific_Transactivation_
PMIDS:1906159
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:1906159, PMID:9731539
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
RCADESchmitges2016Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMDREAM_contestInferred - Egr3 (100% AA Identity, Mus musculus)
PBMBarrera2016Inferred - EGR2 (90% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - EGR2 (90% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - EGR2 (90% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Egr2 (90% AA Identity, Mus musculus)
SELEXJASPARInferred - EGR2 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR2 (90% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR2 (90% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EGR2 (90% AA Identity, Homo sapiens)
MiscHOMERInferred - Egr2 (90% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - EGR1 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - EGR1 (88% AA Identity, Homo sapiens)
PBMBerger06Inferred - Egr1 (88% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - Egr1 (88% AA Identity, Mus musculus)
PBMZoo_01Inferred - Egr1 (88% AA Identity, Mus musculus)
PBMBarrera2016Inferred - EGR2 (88% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - EGR2 (88% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - EGR2 (88% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - EGR2 (88% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - EGR1 (88% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - EGR1 (88% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - EGR1 (88% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - EGR1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR1 (88% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EGR1 (88% AA Identity, Homo sapiens)
MiscHOMERInferred - EGR1 (88% AA Identity, Homo sapiens)
PBMBadis09Inferred - Egr1 (87% AA Identity, Mus musculus)
PBMCEPDInferred - egrh-1 (81% AA Identity, Caenorhabditis elegans)
HT-SELEXYin2017Inferred - EGR4 (77% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - EGR4 (77% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - EGR4 (77% AA Identity, Homo sapiens)
MiscHocoMocoInferred - EGR4 (77% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution