TF Info Page for GATA2 (GATA)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: GATA binding protein 2 [Source:HGNC Symbol;Acc:HGNC:4171]
Entrez Summary This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Ensembl ID: ENSG00000179348
External Link: CisBP
Interpro IPR000679; IPR016374;
Protein Domain: ENSP00000345681
Protein Domain: ENSP00000400259
Protein Domain: ENSP00000417074
Protein Domain: ENSP00000419532
Protein Domain: ENSP00000418132
Domain:
Protein: ENSP00000345681DBD: GATAOther:
Protein: ENSP00000400259DBD: GATAOther:
Protein: ENSP00000417074DBD: GATAOther:
Protein: ENSP00000419532DBD: GATAOther:
Protein: ENSP00000418132DBD: GATAOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:9565596 14512418
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0001228
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor
IBA - GO_REF:0000033
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:15016828, PMID:20206639
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqJASPARDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
HT-SELEXYin2017Inferred - GATA3 (97% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA3 (97% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA3 (97% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA3 (97% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gata3 (97% AA Identity, Mus musculus)
SMiLE-seqIsakova2017Inferred - Gata3 (97% AA Identity, Mus musculus)
ChIP-seqENCODEInferred - GATA3 (97% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - GATA3 (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA3 (97% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GATA3 (97% AA Identity, Homo sapiens)
MiscHOMERInferred - Gata3 (97% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (97% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (97% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (97% AA Identity, Mus musculus)
MiscHOMERInferred - Gata3 (97% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - grn (92% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - grn (92% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - grn (92% AA Identity, Drosophila melanogaster)
ChIP-seqJASPARInferred - Gata1 (92% AA Identity, Mus musculus)
HT-SELEXJolma2010Inferred - GATA1 (91% AA Identity, Homo sapiens)
HT-SELEXJolma2010Inferred - GATA1 (91% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA1 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA1 (91% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA1 (91% AA Identity, Homo sapiens)
ChIP-seqENCODEInferred - GATA1 (91% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - GATA1 (91% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - GATA1 (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA1 (91% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GATA1 (91% AA Identity, Homo sapiens)
MiscHOMERInferred - GATA1 (91% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA4 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA4 (88% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - pnr (85% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - pnr (85% AA Identity, Drosophila melanogaster)
ChIP-chipJASPARInferred - pnr (85% AA Identity, Drosophila melanogaster)
ChIP-seqmodENCODEInferred - pnr (85% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - GATA5 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA5 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA5 (82% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - GATA5 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA5 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA5 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA5 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA5 (82% AA Identity, Homo sapiens)
PBMBadis09Inferred - Gata5 (82% AA Identity, Mus musculus)
PBMBadis09Inferred - Gata6 (82% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Gata5 (82% AA Identity, Mus musculus)
MiscHocoMocoInferred - GATA5 (82% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Gata4 (81% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - GATA4 (81% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA4 (81% AA Identity, Homo sapiens)
ChIP-seqJASPARInferred - Gata4 (81% AA Identity, Mus musculus)
MiscHocoMocoInferred - GATA4 (81% AA Identity, Homo sapiens)
MiscHOMERInferred - Gata4 (81% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - srp (80% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - srp (80% AA Identity, Drosophila melanogaster)
MisciDMMPMMInferred - srp (80% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - GATA6 (77% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - GATA6 (77% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA6 (77% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - GATA6 (77% AA Identity, Homo sapiens)
MiscHocoMocoInferred - GATA6 (77% AA Identity, Homo sapiens)
ChIP-seqmodENCODEInferred - elt-1 (74% AA Identity, Caenorhabditis elegans)
ChIP-seqmodENCODEInferred - elt-1 (74% AA Identity, Caenorhabditis elegans)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution