TF Info Page for FOXE1 (Forkhead)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: forkhead box E1 [Source:HGNC Symbol;Acc:HGNC:3806]
Entrez Summary This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016]
Ensembl ID: ENSG00000178919
External Link: CisBP
Interpro IPR001766; IPR018122;
Protein Domain: ENSP00000364265
Protein: ENSP00000364265DBD: ForkheadOther:

Previous Annotations

Source Annotation
TF-CAT classification Indeterminate - There is no evidence for or against this genes role as a TF__TF PPI_
PMIDS:15367491 15223130
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033 | IDA - PMID:24219130 | IMP -
sequence-specific DNA binding transcription factor activity
IDA - PMID:9697705
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
PBMTF_EvolutionUnpublished DataInferred - foxe3 (85% AA Identity, Xenopus tropicalis)
SELEXJASPARInferred - FOXL1 (71% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXL1 (71% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FOXD3 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXD3 (70% AA Identity, Homo sapiens)
PBMBadis09Inferred - Foxl1 (70% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - FOXD3 (70% AA Identity, Homo sapiens)
SELEXJASPARInferred - Foxd3 (70% AA Identity, Rattus norvegicus)
TransfacTransfacLicense requiredInferred - FOXD4L4 (70% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Foxl1 (70% AA Identity, Mus musculus)
MiscHocoMocoInferred - FOXD3 (70% AA Identity, Homo sapiens)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution