TF Info Page for ZNF518A (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif Virtually nothing is known for this protein except that it has a decent cassette of znfC2H2 domains and that it interacts with polycomb repressor complex 2 PMID: 25680957

Description

Description: zinc finger protein 518A [Source:HGNC Symbol;Acc:HGNC:29009]
Entrez Summary The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Numerous transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2016]
Ensembl ID: ENSG00000177853
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000479684
Protein Domain: ENSP00000480280
Protein Domain: ENSP00000485614
Protein Domain: ENSP00000481657
Domain:
Protein: ENSP00000479684DBD: C2H2 ZF Containing ProteinsOther: zf-H2C2_2, zf-H2C2_5
Protein: ENSP00000480280DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000485614DBD: C2H2 ZF Containing ProteinsOther: zf-H2C2_2, zf-H2C2_5
Protein: ENSP00000481657DBD: C2H2 ZF Containing ProteinsOther: zf-H2C2_2, zf-H2C2_5

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution