The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif

Description

Description:	THAP domain containing 5 [Source:HGNC Symbol;Acc:HGNC:23188]
Entrez Summary	TBA
Ensembl ID:	ENSG00000177683
External Link:	T152767_1.02
Interpro	IPR006612; ;
Protein Domain:
Protein: ENSP00000322440	DBD: THAP	Other: ADIP
Protein: ENSP00000400500	DBD: THAP	Other: ADIP
Protein: ENSP00000415841	DBD: THAP	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	c
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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{"regions": [{"startStyle": "curved", "end": 84, "endStyle": "curved", "aliStart": 5, "text": "THAP", "colour": "#009900", "aliEnd": 84, "start": 5, "href": "http://pfam.xfam.org/family/PF05485.10", "type": "pfama", "display": "true", "metadata": {"end": 84, "description": "The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes [1].", "database": "PfamA", "aliStart": 5, "scoreName": "E-value", "accession": "PF05485.10", "start": 5, "score": 1.1e-15, "identifier": "THAP domain", "type": "DBD", "aliEnd": 84}}, {"startStyle": "jagged", "end": 390, "endStyle": "jagged", "aliStart": 315, "text": "ADIP", "colour": "#9999ff", "aliEnd": 387, "start": 311, "href": "http://pfam.xfam.org/family/PF11559.6", "type": "pfama", "display": "true", "metadata": {"end": 390, "description": "This family is found in mammals where it is localised at cell-cell adherens junctions [1], and in Sch. pombe and other fungi where it anchors spindle-pole bodies to spindle microtubules [2]. It is a coiled-coil structure, and in pombe, it is required for anchoring the minus end of spindle microtubules to the centrosome equivalent, the spindle-pole body. The name ADIP derives from the family being composed of Afadin- and alpha -Actinin-Binding Proteins Localised at Cell-Cell Adherens Junctions.", "database": "PfamA", "aliStart": 315, "scoreName": "E-value", "accession": "PF11559.6", "start": 311, "score": 0.0017, "identifier": "Afadin- and alpha -actinin-Binding", "type": "DBD", "aliEnd": 387}}], "length": 396}

{"regions": [{"startStyle": "curved", "end": 54, "endStyle": "jagged", "aliStart": 5, "text": "THAP", "colour": "#009900", "aliEnd": 52, "start": 5, "href": "http://pfam.xfam.org/family/PF05485.10", "type": "pfama", "display": "true", "metadata": {"end": 54, "description": "The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes [1].", "database": "PfamA", "aliStart": 5, "scoreName": "E-value", "accession": "PF05485.10", "start": 5, "score": 5.7999999999999997e-08, "identifier": "THAP domain", "type": "DBD", "aliEnd": 52}}], "length": 56}

TF Info Page for THAP5 (THAP finger)