The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	In vivo/Misc source

Description

Description:	zinc finger and BTB domain containing 33 [Source:HGNC Symbol;Acc:HGNC:16682]
Entrez Summary	TBA
Ensembl ID:	ENSG00000177485
External Link:	T044578_1.02
Interpro	IPR000210; IPR007087; IPR011333; IPR013069; IPR015880; ;
Protein Domain:
Protein: ENSP00000314153	DBD: C2H2 ZF Containing Proteins	Other: BTB, zf-C2H2_4, zf-H2C2_2
Protein: ENSP00000450969	DBD: C2H2 ZF Containing Proteins	Other: BTB, zf-C2H2_4, zf-H2C2_2

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:11445535 14527417
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
Methyl-HT-SELEX	Yin2017		Direct
ChIP-seq	JASPAR		Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Transfac	Transfac	License required	Direct
Misc	HocoMoco		Direct
Misc	HOMER		Direct

Structure

Structure	PDB	2LT7

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "straight", "end": 119, "endStyle": "straight", "aliStart": 22, "text": "BTB", "colour": "#9999ff", "aliEnd": 114, "start": 22, "href": "http://pfam.xfam.org/family/PF00651.29", "type": "pfama", "display": "true", "metadata": {"end": 119, "description": "The BTB (for BR-C, ttk and bab) [1] or POZ (for Pox virus and Zinc finger) [2] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [2]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer.  The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [3]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [4,5,6]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.", "database": "PfamA", "aliStart": 22, "scoreName": "E-value", "accession": "PF00651.29", "start": 22, "score": 3.2000000000000003e-20, "identifier": "BTB/POZ domain", "type": "DBD", "aliEnd": 114}}, {"startStyle": "straight", "end": 517, "endStyle": "straight", "aliStart": 494, "text": "zf-C2H2_4", "colour": "#9999ff", "aliEnd": 516, "start": 494, "href": "http://pfam.xfam.org/family/PF13894.4", "type": "pfama", "display": "true", "metadata": {"end": 517, "description": "This family contains a number of divergent C2H2 type zinc fingers.", "database": "PfamA", "aliStart": 494, "scoreName": "E-value", "accession": "PF13894.4", "start": 494, "score": 2e-06, "identifier": "C2H2-type zinc finger", "type": "DBD", "aliEnd": 516}}, {"startStyle": "straight", "end": 545, "endStyle": "straight", "aliStart": 522, "text": "zf-C2H2_4", "colour": "#9999ff", "aliEnd": 544, "start": 522, "href": "http://pfam.xfam.org/family/PF13894.4", "type": "pfama", "display": "true", "metadata": {"end": 545, "description": "This family contains a number of divergent C2H2 type zinc fingers.", "database": "PfamA", "aliStart": 522, "scoreName": "E-value", "accession": "PF13894.4", "start": 522, "score": 2e-06, "identifier": "C2H2-type zinc finger", "type": "DBD", "aliEnd": 544}}, {"startStyle": "straight", "end": 573, "endStyle": "straight", "aliStart": 550, "text": "zf-C2H2_4", "colour": "#9999ff", "aliEnd": 573, "start": 550, "href": "http://pfam.xfam.org/family/PF13894.4", "type": "pfama", "display": "true", "metadata": {"end": 573, "description": "This family contains a number of divergent C2H2 type zinc fingers.", "database": "PfamA", "aliStart": 550, "scoreName": "E-value", "accession": "PF13894.4", "start": 550, "score": 2e-06, "identifier": "C2H2-type zinc finger", "type": "DBD", "aliEnd": 573}}, {"startStyle": "straight", "end": 532, "endStyle": "straight", "aliStart": 508, "text": "zf-H2C2_2", "colour": "#9999ff", "aliEnd": 531, "start": 508, "href": "http://pfam.xfam.org/family/PF13465.4", "type": "pfama", "display": "true", "metadata": {"end": 532, "description": NaN, "database": "PfamA", "aliStart": 508, "scoreName": "E-value", "accession": "PF13465.4", "start": 508, "score": 4.2999999999999995e-06, "identifier": "Zinc-finger double domain", "type": "DBD", "aliEnd": 531}}, {"startStyle": "jagged", "end": 561, "endStyle": "straight", "aliStart": 538, "text": "zf-H2C2_2", "colour": "#9999ff", "aliEnd": 560, "start": 537, "href": "http://pfam.xfam.org/family/PF13465.4", "type": "pfama", "display": "true", "metadata": {"end": 561, "description": NaN, "database": "PfamA", "aliStart": 538, "scoreName": "E-value", "accession": "PF13465.4", "start": 537, "score": 4.2999999999999995e-06, "identifier": "Zinc-finger double domain", "type": "DBD", "aliEnd": 560}}], "length": 673}

TF Info Page for ZBTB33 (C2H2 ZF(non-KRAB))