TF Info Page for NR2C2 (Nuclear receptor)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: nuclear receptor subfamily 2 group C member 2 [Source:HGNC Symbol;Acc:HGNC:7972]
Entrez Summary This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]
Ensembl ID: ENSG00000177463
External Link: CisBP
Interpro IPR000536; IPR001628; IPR001723; IPR008946;
Protein Domain: ENSP00000320447
Protein Domain: ENSP00000384463
Protein Domain: ENSP00000483059
Protein Domain: ENSP00000388387
Protein Domain: ENSP00000413438
Protein Domain: ENSP00000391473
Protein Domain: ENSP00000401807
Protein Domain: ENSP00000412473
Domain:
Protein: ENSP00000320447DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000384463DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000483059DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000388387DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000413438DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000391473DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000401807DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000412473DBD: Nuclear Hormone ReceptorOther: Hormone_recep

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:9006963
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:10644740
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
ChIP-seqJASPARDirect
ChIP-seqmodENCODEDirect
ChIP-seqmodENCODEDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERDirect
HT-SELEXYin2017Inferred - NR2C1 (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NR2C1 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NR2C1 (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NR2C1 (78% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NR2C1 (78% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Nr2c1 (75% AA Identity, Mus musculus)
PBMZoo_01Inferred - Nr2c1 (75% AA Identity, Mus musculus)
PBMZoo_01Inferred - O77476_BRUPA (74% AA Identity, Brugia pahangi)
PBMZoo_01Inferred - Q969A9_BOMMO (71% AA Identity, Bombyx mori)
PBMZoo_01Inferred - Smp_105090 (70% AA Identity, Schistosoma mansoni)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution