TF Info Page for TGIF1 (Homeodomain)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | TGFB induced factor homeobox 1 [Source:HGNC Symbol;Acc:HGNC:11776] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Summary | The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl ID: | ENSG00000177426 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Link: | CisBP | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Interpro | IPR001356; IPR008422; IPR009057; ; | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000327959 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000339631 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000385206 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000384970 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000449501 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000446944 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000450025 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000449287 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000483499 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000343969 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000383031 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000384133 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000448934 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000447747 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000449973 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000449722 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000449531 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000446838 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000462285 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Domain: |
|
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:8537382 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:10764806 | IMP - PMID:10764806 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:8537382 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |