TF Info Page for ZBTB38 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif It has a decent cassette of znfC2H2 domains and a BTB homodimerization domain. Requires CpG methylation for binding into a site in MYOG-promoter (PMID: 21625269).

Description

Description: zinc finger and BTB domain containing 38 [Source:HGNC Symbol;Acc:HGNC:26636]
Entrez Summary The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq, Jun 2010]
Ensembl ID: ENSG00000177311
External Link: CisBP
Interpro IPR000210; IPR007087; IPR011333; IPR013069; IPR015880; ;
Protein Domain: ENSP00000426931
Protein Domain: ENSP00000424254
Protein Domain: ENSP00000422757
Protein Domain: ENSP00000406955
Protein Domain: ENSP00000421037
Protein Domain: ENSP00000425705
Protein Domain: ENSP00000426387
Protein Domain: ENSP00000422347
Protein Domain: ENSP00000422894
Protein Domain: ENSP00000422081
Protein Domain: ENSP00000372635
Protein Domain: ENSP00000490370
Protein Domain: ENSP00000490041
Domain:
Protein: ENSP00000426931DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000424254DBD: C2H2 ZF Containing ProteinsOther: BTB, zf-C2H2_4, zf-C2H2_6
Protein: ENSP00000422757DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000406955DBD: C2H2 ZF Containing ProteinsOther: BTB, zf-C2H2_4, zf-C2H2_6
Protein: ENSP00000421037DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000425705DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000426387DBD: C2H2 ZF Containing ProteinsOther: BTB, zf-C2H2_4, zf-C2H2_6
Protein: ENSP00000422347DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000422894DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000422081DBD: C2H2 ZF Containing ProteinsOther: BTB
Protein: ENSP00000372635DBD: C2H2 ZF Containing ProteinsOther: BTB, zf-C2H2_4, zf-C2H2_6
Protein: ENSP00000490370DBD: C2H2 ZF Containing ProteinsOther: BTB, zf-C2H2_4, zf-C2H2_6
Protein: ENSP00000490041DBD: C2H2 ZF Containing ProteinsOther: BTB, zf-C2H2_4, zf-C2H2_6

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
ISS - GO_REF:0000024
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution