The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif

Description

Description:	THAP domain containing 4 [Source:HGNC Symbol;Acc:HGNC:23187]
Entrez Summary	TBA
Ensembl ID:	ENSG00000176946
External Link:
Interpro	IPR006612; IPR011038; IPR014878; ;
Protein Domain:
Protein: ENSP00000385931	DBD: THAP	Other: DUF1794
Protein: ENSP00000385006	DBD: THAP	Other: DUF1794, DUF4201, HrpB7
Protein: ENSP00000482312	DBD: THAP	Other: DUF1794, DUF4201, HrpB7, IncA
Protein: ENSP00000384352	DBD: THAP	Other: DUF1794

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	c
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "curved", "end": 85, "endStyle": "curved", "aliStart": 5, "text": "THAP", "colour": "#009900", "aliEnd": 85, "start": 5, "href": "http://pfam.xfam.org/family/PF05485.10", "type": "pfama", "display": "true", "metadata": {"end": 85, "description": "The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes [1].", "database": "PfamA", "aliStart": 5, "scoreName": "E-value", "accession": "PF05485.10", "start": 5, "score": 5.5e-19, "identifier": "THAP domain", "type": "DBD", "aliEnd": 85}}, {"startStyle": "straight", "end": 574, "endStyle": "straight", "aliStart": 422, "text": "DUF1794", "colour": "#9999ff", "aliEnd": 574, "start": 421, "href": "http://pfam.xfam.org/family/PF08768.9", "type": "pfama", "display": "true", "metadata": {"end": 574, "description": "This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.", "database": "PfamA", "aliStart": 422, "scoreName": "E-value", "accession": "PF08768.9", "start": 421, "score": 1.6e-42, "identifier": "Domain of unknown function (DUF1794)", "type": "DBD", "aliEnd": 574}}, {"startStyle": "jagged", "end": 401, "endStyle": "jagged", "aliStart": 353, "text": "HrpB7", "colour": "#9999ff", "aliEnd": 399, "start": 315, "href": "http://pfam.xfam.org/family/PF09486.8", "type": "pfama", "display": "true", "metadata": {"end": 401, "description": "This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.", "database": "PfamA", "aliStart": 353, "scoreName": "E-value", "accession": "PF09486.8", "start": 315, "score": 0.0041, "identifier": "Bacterial type III secretion protein (HrpB7)", "type": "DBD", "aliEnd": 399}}, {"startStyle": "jagged", "end": 402, "endStyle": "jagged", "aliStart": 354, "text": "DUF4201", "colour": "#9999ff", "aliEnd": 399, "start": 343, "href": "http://pfam.xfam.org/family/PF13870.4", "type": "pfama", "display": "true", "metadata": {"end": 402, "description": "This is a family of coiled-coil proteins from eukaryotes. The function is not known.", "database": "PfamA", "aliStart": 354, "scoreName": "E-value", "accession": "PF13870.4", "start": 343, "score": 0.0049, "identifier": "Domain of unknown function (DUF4201)", "type": "DBD", "aliEnd": 399}}], "length": 578}

{"regions": [{"startStyle": "straight", "end": 169, "endStyle": "jagged", "aliStart": 97, "text": "DUF1794", "colour": "#9999ff", "aliEnd": 167, "start": 96, "href": "http://pfam.xfam.org/family/PF08768.9", "type": "pfama", "display": "true", "metadata": {"end": 169, "description": "This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.", "database": "PfamA", "aliStart": 97, "scoreName": "E-value", "accession": "PF08768.9", "start": 96, "score": 3.8e-18, "identifier": "Domain of unknown function (DUF1794)", "type": "DBD", "aliEnd": 167}}, {"startStyle": "jagged", "end": 77, "endStyle": "jagged", "aliStart": 29, "text": "DUF4201", "colour": "#9999ff", "aliEnd": 74, "start": 18, "href": "http://pfam.xfam.org/family/PF13870.4", "type": "pfama", "display": "true", "metadata": {"end": 77, "description": "This is a family of coiled-coil proteins from eukaryotes. The function is not known.", "database": "PfamA", "aliStart": 29, "scoreName": "E-value", "accession": "PF13870.4", "start": 18, "score": 0.0009699999999999999, "identifier": "Domain of unknown function (DUF4201)", "type": "DBD", "aliEnd": 74}}, {"startStyle": "jagged", "end": 76, "endStyle": "jagged", "aliStart": 28, "text": "HrpB7", "colour": "#9999ff", "aliEnd": 74, "start": 24, "href": "http://pfam.xfam.org/family/PF09486.8", "type": "pfama", "display": "true", "metadata": {"end": 76, "description": "This entry represents proteins encoded by genes which are found in type III secretion operons in a narrow range of species including Xanthomonas, Burkholderia and Ralstonia.", "database": "PfamA", "aliStart": 28, "scoreName": "E-value", "accession": "PF09486.8", "start": 24, "score": 0.0011, "identifier": "Bacterial type III secretion protein (HrpB7)", "type": "DBD", "aliEnd": 74}}, {"startStyle": "jagged", "end": 90, "endStyle": "jagged", "aliStart": 30, "text": "IncA", "colour": "#9999ff", "aliEnd": 73, "start": 19, "href": "http://pfam.xfam.org/family/PF04156.12", "type": "pfama", "display": "true", "metadata": {"end": 90, "description": "Chlamydia trachomatis is an obligate intracellular bacterium that develops within a parasitophorous vacuole termed an inclusion. The inclusion is non-fusogenic with lysosomes but intercepts lipids from a host cell exocytic pathway. Initiation of chlamydial development is concurrent with modification of the inclusion membrane by a set of C.  trachomatis-encoded proteins collectively designated Incs. One of these Incs, IncA, is functionally associated with the homotypic fusion of inclusions [1]. This family probably includes members of the wider Inc family rather than just IncA. Members are usually either 2 or 4TM proteins.", "database": "PfamA", "aliStart": 30, "scoreName": "E-value", "accession": "PF04156.12", "start": 19, "score": 0.0067, "identifier": "IncA protein", "type": "DBD", "aliEnd": 73}}], "length": 170}

{"regions": [{"startStyle": "straight", "end": 131, "endStyle": "jagged", "aliStart": 10, "text": "DUF1794", "colour": "#9999ff", "aliEnd": 126, "start": 9, "href": "http://pfam.xfam.org/family/PF08768.9", "type": "pfama", "display": "true", "metadata": {"end": 131, "description": "This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.", "database": "PfamA", "aliStart": 10, "scoreName": "E-value", "accession": "PF08768.9", "start": 9, "score": 2.2999999999999998e-39, "identifier": "Domain of unknown function (DUF1794)", "type": "DBD", "aliEnd": 126}}, {"startStyle": "jagged", "end": 189, "endStyle": "straight", "aliStart": 152, "text": "DUF1794", "colour": "#9999ff", "aliEnd": 189, "start": 146, "href": "http://pfam.xfam.org/family/PF08768.9", "type": "pfama", "display": "true", "metadata": {"end": 189, "description": "This domain forms a beta barrel structure but the function is unknown. The GO annotation for this protein indicates that the protein has a function in nematode larval development and has a positive regulation on growth rate.", "database": "PfamA", "aliStart": 152, "scoreName": "E-value", "accession": "PF08768.9", "start": 146, "score": 2.2999999999999998e-39, "identifier": "Domain of unknown function (DUF1794)", "type": "DBD", "aliEnd": 189}}], "length": 193}

TF Info Page for THAP4 (THAP finger)