TF Info Page for FOXC2 (Forkhead)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: forkhead box C2 [Source:HGNC Symbol;Acc:HGNC:3801]
Entrez Summary This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000176692
External Link: CisBP
Interpro IPR001766; IPR018122;
Protein Domain: ENSP00000326371
Domain:
Protein: ENSP00000326371DBD: ForkheadOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:20956529
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA - PMID:9169153
GO:0003705
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
MiscHocoMocoDirect
PBMDREAM_contestInferred - Foxc2 (100% AA Identity, Mus musculus)
PBMBarrera2016Inferred - FOXC1 (97% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Foxc1 (97% AA Identity, Mus musculus)
SELEXJASPARInferred - FOXC1 (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXC1 (97% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXC1 (97% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FOXC1 (97% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - FOXC1 (96% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - FOXC1 (96% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - FOXC1 (96% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - FOXC1 (96% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - FOXC1 (96% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - FOXC1 (96% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - croc (88% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - croc (88% AA Identity, Drosophila melanogaster)
PBMBadis09Inferred - Foxl1 (80% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Foxl1 (80% AA Identity, Mus musculus)
SELEXJASPARInferred - FOXL1 (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXL1 (78% AA Identity, Homo sapiens)
PBMTF_EvolutionUnpublished DataInferred - foxe3 (72% AA Identity, Xenopus tropicalis)
HT-SELEXYin2017Inferred - FOXD3 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXD3 (70% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXD3 (70% AA Identity, Homo sapiens)
SELEXJASPARInferred - Foxd3 (70% AA Identity, Rattus norvegicus)
MiscHocoMocoInferred - FOXD3 (70% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution