TF Info Page for MLXIP (bHLH)


Assessment Binding Mode Motif Status Notes Comments
Inferred motif 2 Obligate heteromer High-throughput in vitro


Description: MLX interacting protein [Source:HGNC Symbol;Acc:HGNC:17055]
Entrez Summary This gene encodes a protein that functions as part of a heterodimer to activate transcription. The encoded protein forms a heterodimer with Max-like protein X (MLX) and is involved in the regulation of genes in response to cellular glucose levels. [provided by RefSeq, Mar 2014]
Ensembl ID: ENSG00000175727
External Link: CisBP
Interpro IPR011598; ;
Protein Domain: ENSP00000312834
Protein Domain: ENSP00000440769
Protein Domain: ENSP00000438206
Protein Domain: ENSP00000444507
Protein Domain: ENSP00000445891
Protein: ENSP00000312834DBD: bHLHOther:
Protein: ENSP00000440769DBD: bHLHOther:
Protein: ENSP00000438206DBD: bHLHOther:
Protein: ENSP00000444507DBD: bHLHOther:
Protein: ENSP00000445891DBD: bHLHOther:

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
PBMZoo_01Inferred - Mlxip (66% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - MLXIPL (58% AA Identity, Homo sapiens)
MiscHocoMocoInferred - MLXIPL (58% AA Identity, Homo sapiens)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution