TF Info Page for DDIT3 (bZIP)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 2 Obligate heteromer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | Has strong preference for forming heterodimers with BATF; DBP; HLF; CEBP[ABCD] over homodimerization (PMID: 12805554). |
Description
| Description: | DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000175197 | |
| External Link: | T025314_1.02 | |
| Interpro | IPR004827; IPR016670; | |
| Protein Domain: | ||
| Protein: ENSP00000340671 | DBD: bZIP | Other: |
| Protein: ENSP00000448665 | DBD: bZIP | Other: |
| Protein: ENSP00000447803 | DBD: bZIP | Other: |
| Protein: ENSP00000447188 | DBD: bZIP | Other: |
| Protein: ENSP00000447503 | DBD: bZIP | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific Transcription Factor Binding tf co-factor binding_Co-activation_ PMIDS:8657121 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:22065586 GO:0003700 sequence-specific DNA binding transcription factor activity IC - PMID:15322075 | IGI - PMID:24939851 GO:0032792 negative regulation of CREB transcription factor activity IDA - PMID:8622660 | IGI - PMID:11478948 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA - PMID:16434966 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements | Obligate_Multimer |