TF Info Page for DDIT3 (bZIP)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 2 Obligate heteromer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain | Has strong preference for forming heterodimers with BATF; DBP; HLF; CEBP[ABCD] over homodimerization (PMID: 12805554). |
Description
| Description: | DNA damage inducible transcript 3 [Source:HGNC Symbol;Acc:HGNC:2726] | |||||||||||||||
| Entrez Summary | This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010] | |||||||||||||||
| Ensembl ID: | ENSG00000175197 | |||||||||||||||
| External Link: | CisBP | |||||||||||||||
| Interpro | IPR004827; IPR016670; | |||||||||||||||
| Protein Domain: | ENSP00000340671 | |||||||||||||||
| Protein Domain: | ENSP00000448665 | |||||||||||||||
| Protein Domain: | ENSP00000447803 | |||||||||||||||
| Protein Domain: | ENSP00000447188 | |||||||||||||||
| Protein Domain: | ENSP00000447503 | |||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific Transcription Factor Binding tf co-factor binding_Co-activation_ PMIDS:8657121 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:22065586 GO:0003700 sequence-specific DNA binding transcription factor activity IC - PMID:15322075 | IGI - PMID:24939851 GO:0032792 negative regulation of CREB transcription factor activity IDA - PMID:8622660 | IGI - PMID:11478948 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IDA - PMID:16434966 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements | Obligate_Multimer |