The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Likely to be sequence specific TF	1 Monomer or homomultimer	No motif

Description

Description:	zinc fingers and homeoboxes 3 [Source:HGNC Symbol;Acc:HGNC:15935]
Entrez Summary	TBA
Ensembl ID:	ENSG00000174306
External Link:
Interpro	IPR001356; IPR009057; IPR015880; IPR024578;
Protein Domain:
Protein: ENSP00000405421	DBD: Homeodomain	Other:
Protein: ENSP00000443783	DBD: Homeodomain	Other: Homez
Protein: ENSP00000452965	DBD: Homeodomain	Other:
Protein: ENSP00000454006	DBD: Homeodomain	Other:
Protein: ENSP00000362358	DBD: Homeodomain	Other:
Protein: ENSP00000415498	DBD: Homeodomain	Other:
Protein: ENSP00000401852	DBD: Homeodomain	Other:
Protein: ENSP00000399433	DBD: Homeodomain	Other: zf-Di19
Protein: ENSP00000453310	DBD: Homeodomain	Other: Homez
Protein: ENSP00000403048	DBD: Homeodomain	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	No PMIDS:
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:12659632
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

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TF Info Page for ZHX3 (Homeodomain)