Assessment | Binding Mode | Motif Status | Notes | Comments |
---|---|---|---|---|
Inferred motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description: | hes family bHLH transcription factor 3 [Source:HGNC Symbol;Acc:HGNC:26226] | |||
Entrez Summary | #!usr/local/bin/perl ?> Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding activity; and N-box binding activity. Predicted to be involved in several processes, including Notch signaling pathway; negative regulation of neuron differentiation; and regulation of neurogenesis. Predicted to act upstream of or within several processes, including nervous system development; regulation of timing of neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022] | |||
Ensembl ID: | ENSG00000173673 | |||
External Link: | CisBP | |||
Interpro | IPR011598; ; | |||
Protein Domain: | ENSP00000367130 | |||
Domain: |
|
Source | Annotation |
TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:10858455 |
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
c |
CisBP considers it as a TF? | Yes |
TFclass considers it as a TF? | Yes |
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
GO-Info | |
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
4a, two or more datasets predict it as a TF |
TF has conditional DNA-binding requirements |