TF Info Page for DMRT2 (DM)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: doublesex and mab-3 related transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:2935]
Entrez Summary The protein encoded by this gene belongs to the DMRT gene family, sharing a DM DNA-binding domain with Drosophila 'doublesex' (dsx) and C. elegans mab3, genes involved in sex determination in these organisms. Also, this gene is located in a region of the human genome (chromosome 9p24.3) associated with gonadal dysgenesis and XY sex reversal. Hence this gene is one of the candidates for sex-determining gene(s) on chr 9. [provided by RefSeq, Apr 2010]
Ensembl ID: ENSG00000173253
External Link: CisBP
Interpro IPR001275; ;
Protein Domain: ENSP00000350865
Protein Domain: ENSP00000371690
Protein Domain: ENSP00000397494
Protein Domain: ENSP00000259622
Protein: ENSP00000350865DBD: DMOther:
Protein: ENSP00000371690DBD: DMOther:
Protein: ENSP00000397494DBD: DMOther:
Protein: ENSP00000259622DBD: DMOther:

Previous Annotations

Source Annotation
TF-CAT classification Indeterminate - There is no evidence for or against this genes role as a TF___
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
HT-SELEXNitta2015Inferred - dmrt99B (85% AA Identity, Drosophila melanogaster)
PBMTF_EvolutionUnpublished DataInferred - dmrt99B (85% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - dmrt99B (85% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - DMRTA2 (82% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DMRTA2 (82% AA Identity, Homo sapiens)
PBMZoo_01Inferred - DMRTA2 (82% AA Identity, Homo sapiens)
PBMZoo_01Inferred - dmrta2 (82% AA Identity, Xenopus tropicalis)
TransfacTransfacLicense requiredInferred - Dmrta2 (82% AA Identity, Mus musculus)


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution