TF Info Page for ESRRA (Nuclear receptor)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description
| Description: | estrogen related receptor alpha [Source:HGNC Symbol;Acc:HGNC:3471] | ||||||||||||||||||
| Entrez Summary | The protein encoded by this gene is a nuclear receptor that is most closely related to the estrogen receptor. This protein acts as a site-specific transcription factor and interacts with members of the PGC-1 family of transcription cofactors to regulate the expression of most genes involved in cellular energy production as well as in the process of mitochondrial biogenesis. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq, Jun 2019] | ||||||||||||||||||
| Ensembl ID: | ENSG00000173153 | ||||||||||||||||||
| External Link: | CisBP | ||||||||||||||||||
| Interpro | IPR000536; IPR001628; IPR001723; IPR008946; IPR024178; IPR027289; | ||||||||||||||||||
| Protein Domain: | ENSP00000000442 | ||||||||||||||||||
| Protein Domain: | ENSP00000384851 | ||||||||||||||||||
| Protein Domain: | ENSP00000385971 | ||||||||||||||||||
| Protein Domain: | ENSP00000441970 | ||||||||||||||||||
| Protein Domain: | ENSP00000444710 | ||||||||||||||||||
| Protein Domain: | ENSP00000439896 | ||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:9271417 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity TAS - PMID:9286700 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |