TF Info Page for ESRRA (Nuclear receptor)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: estrogen related receptor alpha [Source:HGNC Symbol;Acc:HGNC:3471]
Entrez Summary The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Ensembl ID: ENSG00000173153
External Link: CisBP
Interpro IPR000536; IPR001628; IPR001723; IPR008946; IPR024178; IPR027289;
Protein Domain: ENSP00000000442
Protein Domain: ENSP00000384851
Protein Domain: ENSP00000385971
Protein Domain: ENSP00000441970
Protein Domain: ENSP00000444710
Protein Domain: ENSP00000439896
Domain:
Protein: ENSP00000000442DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000384851DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000385971DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000441970DBD: Nuclear Hormone ReceptorOther:
Protein: ENSP00000444710DBD: Nuclear Hormone ReceptorOther: Hormone_recep
Protein: ENSP00000439896DBD: Nuclear Hormone ReceptorOther: Hormone_recep

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding
Transactivation_
PMIDS:9271417
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
GO:0004879
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
TAS - PMID:9286700
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
ChIP-seqENCODEDirect
ChIP-seqENCODEDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMBadis09Inferred - Esrra (100% AA Identity, Mus musculus)
SELEXJASPARInferred - Esrra (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ESRRB (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ESRRB (91% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ESRRG (91% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ESRRG (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ESRRG (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ESRRG (91% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Esrrg (91% AA Identity, Mus musculus)
SELEXJASPARInferred - ESRRB (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ESRRB (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ESRRB (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ESRRG (91% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ESRRG (91% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ESRRB (91% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ESRRG (91% AA Identity, Homo sapiens)
ChIP-seqhmCHIPInferred - Esrrb (90% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - ERR (88% AA Identity, Drosophila melanogaster)
PBMDREAM_contestInferred - Esrrb (88% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution