This gene encodes a member of the F-box protein family which is
characterized by an approximately 40 amino acid motif, the F-box. The F-box
proteins constitute one of the four subunits of ubiquitin protein ligase
complex called SCFs (SKP1-cullin-F-box), which function in
phosphorylation-dependent ubiquitination. The F-box proteins are divided into
3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich
repeats, and Fbxs containing either different protein-protein interaction
modules or no recognizable motifs. The protein encoded by this gene belongs
to the Fbls class and, in addition to an F-box, contains at least six highly
degenerated leucine-rich repeats. This family member plays a role in
epigenetic silencing. It nucleates at CpG islands and specifically
demethylates both mono- and di-methylated lysine-36 of histone H3.
Alternative splicing results in multiple transcript variants. [provided by
RefSeq, Jan 2012]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
No
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
5a, one of the source datasets predicts is as a TF