TF Info Page for RELA (Rel)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Can bind as a homodimer or heterodimer (PMID: 22101729) |
Description
| Description: | RELA proto-oncogene, NF-kB subunit [Source:HGNC Symbol;Acc:HGNC:9955] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000173039 | |
| External Link: | T138173_1.02 | |
| Interpro | IPR000451; IPR002909; IPR008967; IPR011539; IPR014756; IPR030492; | |
| Protein Domain: | ||
| Protein: ENSP00000311508 | DBD: RHD | Other: RHD_dimer |
| Protein: ENSP00000384273 | DBD: RHD | Other: RHD_dimer |
| Protein: ENSP00000432537 | DBD: RHD | Other: RHD_dimer |
| Protein: ENSP00000431304 | DBD: RHD | Other: |
| Protein: ENSP00000483705 | DBD: RHD | Other: RHD_dimer |
| Protein: ENSP00000434098 | DBD: RHD | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:1935902 15485852 15857826 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0000983 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity IMP - PMID:26268439 GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:17350185 GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:17350185 GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involv IDA - PMID:1406630 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:12048232 GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity IDA - PMID:3091258 GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA - PMID:15790681 | TAS - Reactome:R-HSA-445989 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements |