TF Info Page for KLF11 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: Kruppel like factor 11 [Source:HGNC Symbol;Acc:HGNC:11811]
Entrez Summary The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Ensembl ID: ENSG00000172059
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000307023
Protein Domain: ENSP00000388263
Protein Domain: ENSP00000442722
Protein Domain: ENSP00000444690
Protein Domain: ENSP00000386058
Domain:
Protein: ENSP00000307023DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000388263DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000442722DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000444690DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000386058DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IDA - PMID:21171965
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:9748269
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMBarrera2016Direct
PBMBarrera2016Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
HT-SELEXYin2017Inferred - KLF10 (81% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF10 (81% AA Identity, Homo sapiens)
ChIP-seqNajafabadi2015Inferred - KLF10 (81% AA Identity, Homo sapiens)
ChIP-seqSchmitges2016Inferred - KLF10 (81% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - KLF13 (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - KLF13 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF13 (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF13 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ENSG00000275746 (75% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Klf16 (75% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - KLF16 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF16 (73% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - cbt (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - cbt (71% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - KLF14 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - KLF14 (71% AA Identity, Homo sapiens)
ChIP-seqSchmitges2016Inferred - KLF14 (71% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution