TF Info Page for CAMTA1 (CG-1)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif Binds CGCATTGCG based on EMSA performed in (PMID: 25049392)

Description

Description: calmodulin binding transcription activator 1 [Source:HGNC Symbol;Acc:HGNC:18806]
Entrez Summary The protein encoded by this gene contains a CG1 DNA-binding domain, a transcription factor immunoglobulin domain, ankyrin repeats, and calmodulin-binding IQ motifs. The encoded protein is thought to be a transcription factor and may be a tumor suppressor. However, a translocation event is sometimes observed between this gene and the WWTR1 gene, with the resulting WWTR1-CAMTA1 oncoprotein leading to epithelioid hemangioendothelioma, a malignant vascular cancer. [provided by RefSeq, Mar 2017]
Ensembl ID: ENSG00000171735
External Link: CisBP
Interpro IPR000048; IPR002110; IPR002909; IPR005559; IPR014756; IPR020683; IPR027417; ;
Protein Domain: ENSP00000306522
Protein Domain: ENSP00000451388
Protein Domain: ENSP00000452319
Protein Domain: ENSP00000452024
Protein Domain: ENSP00000451720
Protein Domain: ENSP00000451510
Protein Domain: ENSP00000450530
Domain:
Protein: ENSP00000306522DBD: CG-1Other: Ank_2, Ank_3, Ank_4, Ank_5, IQ, TIG
Protein: ENSP00000451388DBD: CG-1Other:
Protein: ENSP00000452319DBD: CG-1Other: IQ
Protein: ENSP00000452024DBD: CG-1Other: IQ
Protein: ENSP00000451720DBD: CG-1Other: Ank, Ank_2, Ank_3, Ank_4, Ank_5, IQ
Protein: ENSP00000451510DBD: CG-1Other:
Protein: ENSP00000450530DBD: CG-1Other:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution