TF Info Page for BPTF (Unknown)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain; Has a putative AT-hook | (PMID: 10575013) obtained a motif by SELEX and showed that mutating the sequence diminished binding in vitro. Unusual for a PHD/Ring finger, but its there in the literature. |
Description
| Description: | bromodomain PHD finger transcription factor [Source:HGNC Symbol;Acc:HGNC:3581] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000171634 | |
| External Link: | ||
| Interpro | IPR001487; IPR001965; IPR004022; IPR011011; IPR018359; IPR018500; IPR018501; IPR019786; IPR019787; IPR028942; | |
| Protein Domain: | ||
| Protein: ENSP00000307208 | DBD: Other | Other: Bromodomain, DDT, PHD, WHIM1, WSD |
| Protein: ENSP00000343837 | DBD: Other | Other: Bromodomain, PHD |
| Protein: ENSP00000388405 | DBD: Other | Other: Bromodomain, DDT, PHD, WHIM1, WSD |
| Protein: ENSP00000462535 | DBD: Other | Other: |
| Protein: ENSP00000463845 | DBD: Other | Other: Bromodomain, DUF4428, PHD |
| Protein: ENSP00000463736 | DBD: Other | Other: Bromodomain |
| Protein: ENSP00000443949 | DBD: Other | Other: |
| Protein: ENSP00000462703 | DBD: Other | Other: Bromodomain |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_Transcription Factor Binding tf co-factor binding DNA-Binding sequence-specific_DNA Binding_ PMIDS:10575013 10727212 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
No |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info | |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements |