TF Info Page for CXXC5 (CxxC)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro


Description: CXXC finger protein 5 [Source:HGNC Symbol;Acc:HGNC:26943]
Entrez Summary The protein encoded by this gene is a retinoid-inducible nuclear protein containing a CXXC-type zinc finger motif. The encoded protein is involved in myelopoiesis, is required for DNA damage-induced p53 activation, regulates the differentiation of C2C12 myoblasts into myocytes, and negatively regulates cutaneous wound healing. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2015]
Ensembl ID: ENSG00000171604
External Link: CisBP
Interpro IPR002857; ;
Protein Domain: ENSP00000302543
Protein Domain: ENSP00000424219
Protein Domain: ENSP00000421057
Protein Domain: ENSP00000425203
Protein Domain: ENSP00000427440
Protein Domain: ENSP00000427379
Protein Domain: ENSP00000422883
Protein Domain: ENSP00000430949
Protein Domain: ENSP00000421866
Protein Domain: ENSP00000423365
Protein Domain: ENSP00000430522
Protein: ENSP00000302543DBD: CxxCOther:
Protein: ENSP00000424219DBD: CxxCOther:
Protein: ENSP00000421057DBD: CxxCOther:
Protein: ENSP00000425203DBD: CxxCOther:
Protein: ENSP00000427440DBD: CxxCOther:
Protein: ENSP00000427379DBD: CxxCOther:
Protein: ENSP00000422883DBD: CxxCOther:
Protein: ENSP00000430949DBD: CxxCOther:
Protein: ENSP00000421866DBD: CxxCOther:
Protein: ENSP00000423365DBD: CxxCOther:
Protein: ENSP00000430522DBD: CxxCOther:

Previous Annotations

Source Annotation
TF-CAT classification No
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? No
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements


Published Motif Data

Source Annotation Motif Evidence
PBMTF_EvolutionUnpublished DataDirect


Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution