TF Info Page for OTP (Homeodomain)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer 100 perc ID - in vitro

Description

Description: orthopedia homeobox [Source:HGNC Symbol;Acc:HGNC:8518]
Entrez Summary This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000171540
External Link: CisBP
Interpro IPR000047; IPR001356; IPR003654; IPR009057; IPR017970; ;
Protein Domain: ENSP00000302814
Domain:
Protein: ENSP00000302814DBD: HomeodomainOther: OAR

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
PBMBerger08Inferred - Otp (100% AA Identity, Mus musculus)
B1HJASPARInferred - otp (92% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - otp (92% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - otp (92% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - PHOX2A (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2A (75% AA Identity, Homo sapiens)
PBMBerger08Inferred - Phox2a (75% AA Identity, Mus musculus)
PBMBarrera2016Inferred - PHOX2B (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - PHOX2B (75% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - PHOX2B (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2B (75% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2B (75% AA Identity, Homo sapiens)
PBMBerger08Inferred - Phox2b (75% AA Identity, Mus musculus)
MiscHOMERInferred - Phox2a (75% AA Identity, Mus musculus)
PBMBarrera2016Inferred - ARX (73% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ARX (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ARX (73% AA Identity, Homo sapiens)
PBMBerger08Inferred - Arx (73% AA Identity, Mus musculus)
B1HJASPARInferred - CG11294 (73% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG11294 (73% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG11294 (73% AA Identity, Drosophila melanogaster)
PBMBarrera2016Inferred - PHOX2B (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Arx (73% AA Identity, Rattus norvegicus)
HT-SELEXYin2017Inferred - ALX1 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX1 (71% AA Identity, Homo sapiens)
PBMBerger08Inferred - Alx1 (71% AA Identity, Mus musculus)
PBMBerger08Inferred - Alx1 (71% AA Identity, Mus musculus)
PBMBarrera2016Inferred - ARX (71% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - ARX (71% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - ARX (71% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - ARX (71% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - ARX (71% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - CG5369 (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG5369 (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG5369 (71% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - Pph13 (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Pph13 (71% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - SHOX (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SHOX (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SHOX (71% AA Identity, Homo sapiens)
PBMZoo_01Inferred - SHOX (71% AA Identity, Homo sapiens)
PBMBerger08Inferred - Shox2 (71% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ALX1 (71% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Shox2 (71% AA Identity, Rattus norvegicus)
MiscHocoMocoInferred - ALX1 (71% AA Identity, Homo sapiens)
B1HJASPARInferred - al (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - al (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG2808 (70% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - DRGX (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DRGX (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OTX2 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OTX2 (70% AA Identity, Homo sapiens)
PBMBerger08Inferred - Otx2 (70% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - UNCX (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - UNCX (70% AA Identity, Homo sapiens)
PBMBerger08Inferred - Uncx (70% AA Identity, Mus musculus)
PBMZoo_01Inferred - uncx4.1 (70% AA Identity, Tetraodon nigroviridis)
TransfacTransfacLicense requiredInferred - Drgx (70% AA Identity, Rattus norvegicus)
TransfacTransfacLicense requiredInferred - OTX2 (70% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - OTX2 (70% AA Identity, Homo sapiens)
MiscHocoMocoInferred - OTX2 (70% AA Identity, Homo sapiens)
MiscHOMERInferred - Otx2 (70% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Alx3 (68% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ALX4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX4 (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Alx4 (68% AA Identity, Mus musculus)
B1HJASPARInferred - oc (68% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - oc (68% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - OTX1 (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OTX1 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OTX1 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OTX1 (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Otx1 (68% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ALX4 (68% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - OTX1 (68% AA Identity, Homo sapiens)
MisciDMMPMMInferred - oc (68% AA Identity, Drosophila melanogaster)
MiscHocoMocoInferred - OTX1 (68% AA Identity, Homo sapiens)
B1HJASPARInferred - CG32532 (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG32532 (66% AA Identity, Drosophila melanogaster)
PBMBarrera2016Inferred - CRX (66% AA Identity, Homo sapiens)
B1HJASPARInferred - hbn (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - hbn (66% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - PHDP (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - PHDP (66% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - repo (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - repo (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - repo (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - repo (66% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - unc-4 (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - unc-4 (66% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution