The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:	homeobox B9 [Source:HGNC Symbol;Acc:HGNC:5120]
Entrez Summary	TBA
Ensembl ID:	ENSG00000170689
External Link:
Interpro	IPR001356; IPR006711; IPR009057; IPR017112; IPR017970; IPR020479;
Protein Domain:
Protein: ENSP00000309439	DBD: Homeodomain	Other: Hox9_act

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_Transcription Factor Binding tf co-factor binding DNA-Binding sequence-specific_DNA Binding TF PPI Transactivation_ PMIDS:1347944 9079637 10617598 11432851
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	No
GO-Info
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Yin2017		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
PBM	Berger08		Inferred - Hoxb9 (100% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXA9 (94% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA9 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA9 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA9 (94% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa9 (94% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXC9 (94% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC9 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC9 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC9 (94% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD9 (94% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD9 (94% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD9 (94% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD9 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD9 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD9 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD9 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD9 (94% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA9 (94% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA9 (94% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA9 (94% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA9 (94% AA Identity, Homo sapiens)
ChIP-seq	JASPAR		Inferred - Hoxa9 (94% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - HOXD9 (94% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXA9 (94% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXA9 (94% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - Hoxa9 (94% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - HOXD9 (94% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxc9 (92% AA Identity, Mus musculus)
ChIP-seq	JASPAR		Inferred - Hoxc9 (92% AA Identity, Mus musculus)
Misc	HOMER		Inferred - Hoxc9 (92% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXA10 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA10 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA10 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA10 (80% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa10 (80% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXC10 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC10 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC10 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC10 (80% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxc10 (80% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD10 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD10 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD10 (80% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (80% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD10 (80% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd10 (80% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - Hoxa10 (80% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - HOXD10 (80% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXD10 (80% AA Identity, Homo sapiens)
PBM	BusserDevelopment2012		Inferred - Abd-B (73% AA Identity, Drosophila melanogaster)
B1H	JASPAR		Inferred - Abd-B (73% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (73% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (73% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (73% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Abd-B (73% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXB8 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB8 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB8 (73% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb8 (73% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXC8 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC8 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC8 (73% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxc8 (73% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - Abd-B (73% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - Abd-B (73% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - HOXC8 (73% AA Identity, Homo sapiens)
Misc	iDMMPMM		Inferred - Abd-B (73% AA Identity, Drosophila melanogaster)
Misc	HocoMoco		Inferred - HOXB8 (73% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXC8 (73% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA5 (71% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA5 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA5 (71% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa5 (71% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXA6 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA6 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA6 (71% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa6 (71% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB5 (71% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB5 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB5 (71% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb5 (71% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD8 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD8 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD8 (71% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd8 (71% AA Identity, Mus musculus)
COMPILED	JASPAR		Inferred - HOXA5 (71% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA5 (71% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXA5 (71% AA Identity, Homo sapiens)
B1H	JASPAR		Inferred - abd-A (70% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - abd-A (70% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - abd-A (70% AA Identity, Drosophila melanogaster)
B1H	JASPAR		Inferred - Antp (70% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXA4 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA4 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa4 (70% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXA7 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA7 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA7 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa7 (70% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxa7 (70% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB6 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB6 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB6 (70% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb6 (70% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxc5 (70% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxc6 (70% AA Identity, Mus musculus)
B1H	JASPAR		Inferred - Scr (70% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Scr (70% AA Identity, Drosophila melanogaster)
PBM	BusserDevelopment2012		Inferred - Ubx (70% AA Identity, Drosophila melanogaster)
B1H	JASPAR		Inferred - Ubx (70% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Ubx (70% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - abd-A (70% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - Antp (70% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - HOXA4 (70% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - HOXA7 (70% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - Ubx (70% AA Identity, Drosophila melanogaster)
Misc	iDMMPMM		Inferred - abd-A (70% AA Identity, Drosophila melanogaster)
Misc	iDMMPMM		Inferred - Antp (70% AA Identity, Drosophila melanogaster)
Misc	HocoMoco		Inferred - HOXA7 (70% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXB6 (70% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXC6 (70% AA Identity, Homo sapiens)
Misc	iDMMPMM		Inferred - Ubx (70% AA Identity, Drosophila melanogaster)
B1H	JASPAR		Inferred - ftz (68% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - ftz (68% AA Identity, Drosophila melanogaster)
PBM	Berger08		Inferred - Hoxb3 (68% AA Identity, Mus musculus)
PBM	Barrera2016		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb7 (68% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD11 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD11 (68% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd11 (68% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD4 (68% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXD4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD4 (68% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - Q0N4M8_NEMVE (68% AA Identity, Nematostella vectensis)
Transfac	Transfac	License required	Inferred - ftz (68% AA Identity, Drosophila melanogaster)
Misc	iDMMPMM		Inferred - ftz (68% AA Identity, Drosophila melanogaster)
Misc	HocoMoco		Inferred - HOXB7 (68% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - HOXD4 (68% AA Identity, Homo sapiens)
B1H	JASPAR		Inferred - Dfd (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Dfd (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - Dfd (66% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - HOXA11 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA11 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA11 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA11 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa11 (66% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - HOXA2 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxa2 (66% AA Identity, Mus musculus)
PBM	Badis09		Inferred - Hoxa3 (66% AA Identity, Mus musculus)
PBM	Berger08		Inferred - Hoxa3 (66% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXB2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB2 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB2 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXB4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXB4 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxb4 (66% AA Identity, Mus musculus)
PBM	Barrera2016		Inferred - HOXB7 (66% AA Identity, Homo sapiens)
PBM	Barrera2016		Inferred - HOXB7 (66% AA Identity, Homo sapiens)
PBM	Barrera2016		Inferred - HOXC4 (66% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - HOXC4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC4 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXC4 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxc4 (66% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - HOXD3 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD3 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - HOXD3 (66% AA Identity, Homo sapiens)
PBM	Berger08		Inferred - Hoxd3 (66% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - Dfd (66% AA Identity, Drosophila melanogaster)
Transfac	Transfac	License required	Inferred - HOXA3 (66% AA Identity, Homo sapiens)
ChIP-seq	modENCODE		Inferred - lin-39 (66% AA Identity, Caenorhabditis elegans)
Misc	iDMMPMM		Inferred - Dfd (66% AA Identity, Drosophila melanogaster)
Misc	HOMER		Inferred - Hoxa2 (66% AA Identity, Mus musculus)
Misc	HOMER		Inferred - Hoxb4 (66% AA Identity, Mus musculus)
Misc	HOMER		Inferred - lin-39 (66% AA Identity, Caenorhabditis elegans)

Structure

Structure	PDB	Not_Covered

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

{"regions": [{"startStyle": "curved", "end": 242, "endStyle": "curved", "aliStart": 186, "text": "HD", "colour": "#228B22", "aliEnd": 242, "start": 186, "href": "http://pfam.xfam.org/family/PF00046.27", "type": "pfama", "display": "true", "metadata": {"end": 242, "description": "The homeobox domain or homeodomain was first identified in a number of drosophila homeotic and segmentation proteins, but is now known to be well-conserved in many other animals, including vertebrates [PUBMED:2568852, PUBMED:1357790]. Hox genes encode homeodomain-containing transcriptional regulators that operate differential genetic programs along the anterior-posterior axis of animal bodies [PUBMED:12445403]. The domain binds DNA through a helix-turn-helix (HTH) structure. ", "database": "PfamA", "aliStart": 186, "scoreName": "E-value", "accession": "PF00046.27", "start": 186, "score": 8.899999999999999e-21, "identifier": "Homeobox domain", "type": "DBD", "aliEnd": 242}}, {"startStyle": "straight", "end": 172, "endStyle": "straight", "aliStart": 1, "text": "Hox9_act", "colour": "#9999ff", "aliEnd": 172, "start": 1, "href": "http://pfam.xfam.org/family/PF04617.11", "type": "pfama", "display": "true", "metadata": {"end": 172, "description": "This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9.  The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex [1].", "database": "PfamA", "aliStart": 1, "scoreName": "E-value", "accession": "PF04617.11", "start": 1, "score": 4.099999999999999e-56, "identifier": "Hox9 activation region    ", "type": "DBD", "aliEnd": 172}}], "length": 251}

TF Info Page for HOXB9 (Homeodomain)