TF Info Page for PRDM10 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Likely to be sequence specific TF 1 Monomer or homomultimer No motif Has a putative AT-hook

Description

Description: PR domain 10 [Source:HGNC Symbol;Acc:HGNC:13995]
Entrez Summary The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Ensembl ID: ENSG00000170325
External Link: CisBP
Interpro IPR001214; IPR007087; IPR015880; IPR022755;
Protein Domain: ENSP00000302669
Protein Domain: ENSP00000351686
Protein Domain: ENSP00000354118
Protein Domain: ENSP00000398431
Protein Domain: ENSP00000432237
Protein Domain: ENSP00000435940
Protein Domain: ENSP00000432093
Domain:
Protein: ENSP00000302669DBD: C2H2 ZF Containing ProteinsOther: Tristanin_u2
Protein: ENSP00000351686DBD: C2H2 ZF Containing ProteinsOther: Tristanin_u2
Protein: ENSP00000354118DBD: C2H2 ZF Containing ProteinsOther: Tristanin_u2
Protein: ENSP00000398431DBD: C2H2 ZF Containing ProteinsOther: Tristanin_u2
Protein: ENSP00000432237DBD: C2H2 ZF Containing ProteinsOther: Tristanin_u2
Protein: ENSP00000435940DBD: C2H2 ZF Containing ProteinsOther: Tristanin_u2
Protein: ENSP00000432093DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
4a, two or more datasets predict it as a TF
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution