TF Info Page for FOXD4 (Forkhead)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer In vivo/Misc source

Description

Description: forkhead box D4 [Source:HGNC Symbol;Acc:HGNC:3805]
Entrez Summary This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012]
Ensembl ID: ENSG00000170122
External Link: CisBP
Interpro IPR001766; ;
Protein Domain: ENSP00000371940
Domain:
Protein: ENSP00000371940DBD: ForkheadOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0000981
sequence-specific DNA binding RNA polymerase II transcription factor activity
IBA - GO_REF:0000033
GO:0003700
sequence-specific DNA binding transcription factor activity
TAS - PMID:9325056
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a2, Orthologous HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredInferred - ENSG00000204828 (95% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXD4L4 (95% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FOXD2 (88% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FOXD2 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXD2 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXD2 (88% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FOXD3 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXD3 (88% AA Identity, Homo sapiens)
SELEXJASPARInferred - FOXD1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - FOXD1 (88% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - Foxd1 (88% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - FOXD3 (88% AA Identity, Homo sapiens)
SELEXJASPARInferred - Foxd3 (88% AA Identity, Rattus norvegicus)
MiscHocoMocoInferred - FOXD1 (88% AA Identity, Homo sapiens)
MiscHocoMocoInferred - FOXD3 (88% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - fd59A (83% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - fd59A (83% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - fd59A (83% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - fd59A (83% AA Identity, Drosophila melanogaster)
PBMTF_EvolutionUnpublished DataInferred - foxe3 (74% AA Identity, Xenopus tropicalis)
HT-SELEXYin2017Inferred - FOXE1 (70% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FOXE1 (70% AA Identity, Homo sapiens)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution