TF Info Page for ONECUT1 (CUT; Homeodomain)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: one cut homeobox 1 [Source:HGNC Symbol;Acc:HGNC:8138]
Entrez Summary This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Ensembl ID: ENSG00000169856
External Link: CisBP
Interpro IPR001356; IPR003350; IPR009057; IPR010982;
Protein Domain: ENSP00000302630
Protein Domain: ENSP00000453718
Domain:
Protein: ENSP00000302630DBD: CUT, HomeodomainOther:
Protein: ENSP00000453718DBD: CUT, HomeodomainOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:15581617 16618419
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IBA - GO_REF:0000033 | ISS - GO_REF:0000024
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXNitta2015Direct
HT-SELEXYin2017Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
MiscHOMERInferred - Onecut1 (100% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - ONECUT2 (94% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ONECUT2 (94% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ONECUT2 (94% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ONECUT2 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ONECUT2 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ONECUT2 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ONECUT2 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ONECUT2 (94% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ONECUT2 (94% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ONECUT3 (91% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ONECUT3 (91% AA Identity, Homo sapiens)
B1HJASPARInferred - onecut (87% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - onecut (87% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - onecut (87% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - ceh-48 (80% AA Identity, Caenorhabditis elegans)

Structure

Structure PDB 2D5V

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution