TF Info Page for NR0B1 (Unknown)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 2 Obligate heteromer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Description
| Description: | nuclear receptor subfamily 0 group B member 1 [Source:HGNC Symbol;Acc:HGNC:7960] | ||||||
| Entrez Summary | This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism. [provided by RefSeq, Jul 2008] | ||||||
| Ensembl ID: | ENSG00000169297 | ||||||
| External Link: | CisBP | ||||||
| Interpro | IPR000536; IPR001723; IPR008946; IPR025900; | ||||||
| Protein Domain: | ENSP00000368253 | ||||||
| Protein Domain: | ENSP00000368246 | ||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_TF PPI_ PMIDS:16709599 9032275 9384387 10848616 11053406 11427738 9384387 12482977 15155786 15464421 9032275 9384387 9661652 10848616 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA - PMID:7990953 | NAS - PMID:9384387 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity IMP - PMID:19651776 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
2a1, Lower confidence direct evidence |
| TF has conditional DNA-binding requirements |