TF Info Page for MECP2 (MBD; AT hook)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 3 Low specificity DNA-binding protein | 100 perc ID - in vitro | Binds methylated CpG dinucleotides (PDB: 3C2I) |
Description
| Description: | methyl-CpG binding protein 2 [Source:HGNC Symbol;Acc:HGNC:6990] | |
| Entrez Summary | TBA | |
| Ensembl ID: | ENSG00000169057 | |
| External Link: | ||
| Interpro | IPR001739; IPR016177; IPR017353; ; | |
| Protein Domain: | ||
| Protein: ENSP00000301948 | DBD: Methyl-CpG DNA-binding | Other: |
| Protein: ENSP00000395535 | DBD: Methyl-CpG DNA-binding | Other: |
| Protein: ENSP00000486978 | DBD: Methyl-CpG DNA-binding | Other: |
| Protein: ENSP00000489847 | DBD: Methyl-CpG DNA-binding | Other: |
Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_Transcription Regulatory Activity heterochromatin interaction/binding_Non-specific DNA_ PMIDS:8177735 9038338 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
x |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | No |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
| GO-Info |
GO:0003700 sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000019 |
|
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
3a, decent circumstantial evidence for its role as |
| TF has conditional DNA-binding requirements |