TF Info Page for TEF (bZIP)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: TEF, PAR bZIP transcription factor [Source:HGNC Symbol;Acc:HGNC:11722]
Entrez Summary This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Ensembl ID: ENSG00000167074
External Link: CisBP
Interpro IPR004827; ;
Protein Domain: ENSP00000266304
Protein Domain: ENSP00000385256
Protein Domain: ENSP00000411170
Domain:
Protein: ENSP00000266304DBD: bZIPOther:
Protein: ENSP00000385256DBD: bZIPOther:
Protein: ENSP00000411170DBD: bZIPOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:8396764 8440239 14702338
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMZoo_01Inferred - Tef (100% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - HLF (78% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - HLF (78% AA Identity, Homo sapiens)
SELEXJASPARInferred - HLF (78% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - HLF (78% AA Identity, Homo sapiens)
MiscHocoMocoInferred - HLF (78% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - DBP (67% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - DBP (67% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DBP (67% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DBP (67% AA Identity, Homo sapiens)
PBMDREAM_contestInferred - Dbp (67% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - DBP (67% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - DBP (67% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - DBP (67% AA Identity, Homo sapiens)
MiscHocoMocoInferred - DBP (67% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Dbp (66% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution