TF Info Page for STAT6 (STAT)


Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain


Description: signal transducer and activator of transcription 6 [Source:HGNC Symbol;Acc:HGNC:11368]
Entrez Summary The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Ensembl ID: ENSG00000166888
External Link: CisBP
Interpro IPR000980; IPR008967; IPR013799; IPR013800; IPR013801; IPR015988; IPR028187; ;
Protein Domain: ENSP00000300134
Protein Domain: ENSP00000451742
Protein Domain: ENSP00000401486
Protein Domain: ENSP00000444530
Protein Domain: ENSP00000445409
Protein Domain: ENSP00000438451
Protein Domain: ENSP00000450732
Protein Domain: ENSP00000451546
Protein Domain: ENSP00000450428
Protein Domain: ENSP00000450921
Protein Domain: ENSP00000452373
Protein: ENSP00000300134DBD: STATOther: SH2, STAT6_C, STAT_alpha
Protein: ENSP00000451742DBD: STATOther: SH2, STAT6_C, STAT_alpha
Protein: ENSP00000401486DBD: STATOther: SH2, STAT6_C, STAT_alpha
Protein: ENSP00000444530DBD: STATOther: SH2, STAT6_C, STAT_alpha
Protein: ENSP00000445409DBD: STATOther: SH2, STAT6_C, STAT_alpha
Protein: ENSP00000438451DBD: STATOther: SH2, STAT6_C, STAT_alpha
Protein: ENSP00000450732DBD: STATOther: STAT_int
Protein: ENSP00000451546DBD: STATOther: SH2
Protein: ENSP00000450428DBD: STATOther: STAT6_C
Protein: ENSP00000450921DBD: STATOther: SH2
Protein: ENSP00000452373DBD: STATOther: STAT_int

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:7760829 8810328
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a1, Direct HQ evidence
TF has conditional DNA-binding requirements Requires_Phosphorylation


Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
ChIP-seqJASPARInferred - Stat6 (92% AA Identity, Mus musculus)
MiscHOMERInferred - Stat6 (92% AA Identity, Mus musculus)
MiscHOMERInferred - Stat6 (92% AA Identity, Mus musculus)


Structure PDB 4Y5W

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution