TF Info Page for STAT6 (STAT)
Conclusion
| Assessment | Binding Mode | Motif Status | Notes | Comments |
|---|---|---|---|---|
| Known motif | 1 Monomer or homomultimer | In vivo/Misc source | Only known motifs are from Transfac or HocoMoco - origin is uncertain |
Description
| Description: | signal transducer and activator of transcription 6 [Source:HGNC Symbol;Acc:HGNC:11368] | |||||||||||||||||||||||||||||||||
| Entrez Summary | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] | |||||||||||||||||||||||||||||||||
| Ensembl ID: | ENSG00000166888 | |||||||||||||||||||||||||||||||||
| External Link: | CisBP | |||||||||||||||||||||||||||||||||
| Interpro | IPR000980; IPR008967; IPR013799; IPR013800; IPR013801; IPR015988; IPR028187; ; | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000300134 | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000451742 | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000401486 | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000444530 | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000445409 | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000438451 | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000450732 | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000451546 | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000450428 | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000450921 | |||||||||||||||||||||||||||||||||
| Protein Domain: | ENSP00000452373 | |||||||||||||||||||||||||||||||||
| Domain: |
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Previous Annotations
| Source | Annotation |
| TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:7760829 8810328 |
| Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
| CisBP considers it as a TF? | Yes |
| TFclass considers it as a TF? | Yes |
| Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
| GO-Info |
GO:0003700 sequence-specific DNA binding transcription factor activity IEA - GO_REF:0000019 |
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Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
| TF has conditional DNA-binding requirements | Requires_Phosphorylation |