TF Info Page for SALL2 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain

Description

Description: Spalt like transcription factor 2 [Source:HGNC Symbol;Acc:HGNC:10526
Entrez Summary This gene encodes a protein containing multiple zinc finger domains. The encoded protein functions in optical fissure closure during development of the eye in the embryo. Mutations in this gene are associated with ocular coloboma. [provided by RefSeq, Jul 2016]
Ensembl ID: ENSG00000165821
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000484460
Protein Domain: ENSP00000483562
Protein Domain: ENSP00000396773
Protein Domain: ENSP00000438493
Protein Domain: ENSP00000439654
Protein Domain: ENSP00000440054
Protein Domain: ENSP00000483202
Domain:
Protein: ENSP00000484460DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000483562DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_2, zf-C2H2_4, zf-Di19
Protein: ENSP00000396773DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000438493DBD: C2H2 ZF Containing ProteinsOther: DUF2076
Protein: ENSP00000439654DBD: C2H2 ZF Containing ProteinsOther: DUF2076
Protein: ENSP00000440054DBD: C2H2 ZF Containing ProteinsOther: zf-C2H2_4
Protein: ENSP00000483202DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification No
PMIDS:
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info GO:0003700
sequence-specific DNA binding transcription factor activity
IBA - GO_REF:0000033
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution