Only known motifs are from Transfac or HocoMoco - origin is uncertain
Binds CCCCCA based on SELEX (PMID: 14621294).
Description
Description:
zinc finger protein 219 [Source:HGNC Symbol;Acc:HGNC:13011]
Entrez Summary
This gene is a member of the Kruppel-like zinc finger gene family.
The encoded protein functions as a transcriptional repressor of the high
mobility group nucleosome binding domain 1 protein, which is associated with
transcriptionally active chromatin. [provided by RefSeq, Apr 2017]
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
b
CisBP considers it as a TF?
Yes
TFclass considers it as a TF?
Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"
Yes
GO-Info
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IDA - PMID:14621294 GO:0003700 sequence-specific DNA binding transcription factor activity IDA - PMID:14621294, PMID:19549071
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF