Assessment | Binding Mode | Motif Status | Notes | Comments |
---|---|---|---|---|
Known motif | 1 Monomer or homomultimer | High-throughput in vitro |
Description: | PBX/knotted 1 homeobox 2 [Source:HGNC Symbol;Acc:HGNC:16714] | ||||||||||||
Entrez Summary | #!usr/local/bin/perl ?> Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain (Imoto et al., 2001 [PubMed 11549286]).[supplied by OMIM, Oct 2009] | ||||||||||||
Ensembl ID: | ENSG00000165495 | ||||||||||||
External Link: | CisBP | ||||||||||||
Interpro | IPR001356; IPR008422; IPR009057; ; | ||||||||||||
Protein Domain: | ENSP00000298282 | ||||||||||||
Protein Domain: | ENSP00000431599 | ||||||||||||
Protein Domain: | ENSP00000434255 | ||||||||||||
Protein Domain: | ENSP00000453374 | ||||||||||||
Domain: |
|
Source | Annotation |
TF-CAT classification |
TF Gene Candidate_Transcription Factor Binding tf co-factor binding_Co-activation_ PMIDS:11972344 15339927 |
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
b |
CisBP considers it as a TF? | Yes |
TFclass considers it as a TF? | Yes |
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | No |
GO-Info | |
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
TF has conditional DNA-binding requirements |