TF Info Page for UNCX (Homeodomain)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: UNC homeobox [Source:HGNC Symbol;Acc:HGNC:33194]
Entrez Summary This gene encodes a homeobox transcription factor that is involved in somitogenesis and neurogenesis and is required for the maintenance and differentiation of specific elements of the axial skeleton. This gene also plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and deliver hormones that control peripheral functions. The expression of this gene is associated with an increased frequency of acute myeloid leukemia. [provided by RefSeq, Jul 2017]
Ensembl ID: ENSG00000164853
External Link: CisBP
Interpro IPR001356; IPR009057; IPR017970; ;
Protein Domain: ENSP00000314480
Domain:
Protein: ENSP00000314480DBD: HomeodomainOther:

Previous Annotations

Source Annotation
TF-CAT classification Indeterminate - There is no evidence for or against this genes role as a TF___
PMIDS:0
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources. 		b
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" No
GO-Info
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF 		1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXJolma2013Direct
HT-SELEXJolma2013Direct
HT-SELEXYin2017Direct
Methyl-HT-SELEXYin2017Direct
PBMBerger08Inferred - Uncx (100% AA Identity, Mus musculus)
PBMZoo_01Inferred - uncx4.1 (98% AA Identity, Tetraodon nigroviridis)
B1HJASPARInferred - unc-4 (80% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - unc-4 (80% AA Identity, Drosophila melanogaster)
PBMBarrera2016Inferred - ARX (77% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ARX (77% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ARX (77% AA Identity, Homo sapiens)
PBMBerger08Inferred - Arx (77% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Arx (77% AA Identity, Rattus norvegicus)
PBMBarrera2016Inferred - ARX (75% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - ARX (75% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - ARX (75% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - ARX (75% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - ARX (75% AA Identity, Homo sapiens)
PBMZoo_01Inferred - si:dkey-43p13.5 (75% AA Identity, Danio rerio)
HT-SELEXYin2017Inferred - ALX1 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX1 (73% AA Identity, Homo sapiens)
PBMBerger08Inferred - Alx1 (73% AA Identity, Mus musculus)
PBMBerger08Inferred - Alx1 (73% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ALX3 (73% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ALX3 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX3 (73% AA Identity, Homo sapiens)
PBMBerger08Inferred - Alx3 (73% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ALX4 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX4 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ALX4 (73% AA Identity, Homo sapiens)
PBMBerger08Inferred - Alx4 (73% AA Identity, Mus musculus)
B1HJASPARInferred - OdsH (73% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - OdsH (73% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - OdsH (73% AA Identity, Drosophila melanogaster)
PBMBarrera2016Inferred - VSX2 (73% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - VSX2 (73% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - VSX2 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - VSX2 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - VSX2 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - VSX2 (73% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - VSX2 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ALX1 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - ALX4 (73% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - VSX2 (73% AA Identity, Homo sapiens)
MiscHocoMocoInferred - ALX1 (73% AA Identity, Homo sapiens)
MiscHocoMocoInferred - VSX2 (73% AA Identity, Homo sapiens)
B1HJASPARInferred - al (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - al (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG2808 (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG5369 (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG5369 (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG5369 (71% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - hbn (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - hbn (71% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - Pph13 (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Pph13 (71% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - repo (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - repo (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - repo (71% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - repo (71% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - SHOX (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SHOX (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - SHOX (71% AA Identity, Homo sapiens)
PBMZoo_01Inferred - SHOX (71% AA Identity, Homo sapiens)
PBMBerger08Inferred - Shox2 (71% AA Identity, Mus musculus)
PBMBarrera2016Inferred - VSX1 (71% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - VSX1 (71% AA Identity, Homo sapiens)
PBMBerger08Inferred - Vsx1 (71% AA Identity, Mus musculus)
PBMZoo_01Inferred - vsx2 (71% AA Identity, Danio rerio)
TransfacTransfacLicense requiredInferred - Shox2 (71% AA Identity, Rattus norvegicus)
B1HJASPARInferred - CG11294 (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG11294 (70% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - CG11294 (70% AA Identity, Drosophila melanogaster)
PBMBerger08Inferred - Otp (70% AA Identity, Mus musculus)
PBMBarrera2016Inferred - VSX1 (70% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - DRGX (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DRGX (68% AA Identity, Homo sapiens)
PBMBarrera2016Inferred - ESX1 (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ESX1 (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ESX1 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ESX1 (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ESX1 (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - PHOX2A (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2A (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Phox2a (68% AA Identity, Mus musculus)
PBMBarrera2016Inferred - PHOX2B (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - PHOX2B (68% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - PHOX2B (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2B (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - PHOX2B (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Phox2b (68% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - RAX (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - RAX (68% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - RAX (68% AA Identity, Homo sapiens)
PBMBerger08Inferred - Rax (68% AA Identity, Mus musculus)
B1HJASPARInferred - Rx (68% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Rx (68% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Rx (68% AA Identity, Drosophila melanogaster)
TransfacTransfacLicense requiredInferred - Drgx (68% AA Identity, Rattus norvegicus)
TransfacTransfacLicense requiredInferred - Rax (68% AA Identity, Rattus norvegicus)
MiscHOMERInferred - Phox2a (68% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - DMBX1 (66% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - DMBX1 (66% AA Identity, Homo sapiens)
PBMBerger08Inferred - Dmbx1 (66% AA Identity, Mus musculus)
PBMBarrera2016Inferred - ESX1 (66% AA Identity, Homo sapiens)
SMiLE-seqIsakova2017Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - Gsc (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - Gsc (66% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - otp (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - otp (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - otp (66% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - PHDP (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - PHDP (66% AA Identity, Drosophila melanogaster)
PBMBarrera2016Inferred - PHOX2B (66% AA Identity, Homo sapiens)
B1HJASPARInferred - Vsx1 (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Vsx1 (66% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - Vsx1 (66% AA Identity, Drosophila melanogaster)
B1HJASPARInferred - Vsx2 (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Vsx2 (66% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - Vsx2 (66% AA Identity, Drosophila melanogaster)
PBMZoo_01Inferred - Vsx2 (66% AA Identity, Drosophila melanogaster)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution