TF Info Page for NEUROD6 (bHLH)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Inferred motif 1 Monomer or homomultimer High-throughput in vitro

Description

Description: neuronal differentiation 6 [Source:HGNC Symbol;Acc:HGNC:13804]
Entrez Summary This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012]
Ensembl ID: ENSG00000164600
External Link: CisBP
Interpro IPR011598; IPR016637; IPR022575; ;
Protein Domain: ENSP00000297142
Domain:
Protein: ENSP00000297142DBD: bHLHOther: Neuro_bHLH

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_Other_
PMIDS:9308961 9454850 12562512
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001077
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IEA - GO_REF:0000019
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
1a2, Orthologous HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
HT-SELEXYin2017Inferred - NEUROD1 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROD1 (94% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROD2 (94% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROD2 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NEUROD1 (94% AA Identity, Homo sapiens)
TransfacTransfacLicense requiredInferred - NEUROD1 (94% AA Identity, Homo sapiens)
MiscHocoMocoInferred - NEUROD1 (94% AA Identity, Homo sapiens)
MiscHOMERInferred - Neurod1 (94% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - NEUROG1 (64% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROG1 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG1 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG1 (64% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Neurog1 (64% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - NEUROG2 (64% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - NEUROG2 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG2 (64% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - NEUROG2 (64% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ATOH1 (61% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - ATOH1 (61% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH1 (61% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH1 (61% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Atoh1 (61% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - ATOH1 (61% AA Identity, Homo sapiens)
SELEXJASPARInferred - Atoh1 (61% AA Identity, Mus musculus)
MiscHOMERInferred - Atoh1 (61% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - BHLHA15 (60% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - BHLHA15 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHA15 (60% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHA15 (60% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Bhlha15 (60% AA Identity, Mus musculus)
HT-SELEXNitta2015Inferred - dimm (60% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - dimm (60% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - ATOH7 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ATOH7 (59% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - amos (55% AA Identity, Drosophila melanogaster)
HT-SELEXNitta2015Inferred - amos (55% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - BHLHE22 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHE22 (55% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Bhlhe22 (55% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - BHLHE23 (55% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - BHLHE23 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHE23 (55% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - BHLHE23 (55% AA Identity, Homo sapiens)
HT-SELEXNitta2015Inferred - Oli (55% AA Identity, Drosophila melanogaster)
HT-SELEXYin2017Inferred - FERD3L (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - FERD3L (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FERD3L (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - FERD3L (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OLIG2 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OLIG2 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OLIG2 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OLIG2 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - OLIG3 (50% AA Identity, Homo sapiens)
PBMZoo_01Inferred - Olig3 (50% AA Identity, Mus musculus)
MiscHOMERInferred - Olig2 (50% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution