TF Info Page for ZNF148 (C2H2 ZF)

Conclusion

Assessment Binding Mode Motif Status Notes Comments
Known motif 1 Monomer or homomultimer In vivo/Misc source Only known motifs are from Transfac or HocoMoco - origin is uncertain

Description

Description: zinc finger protein 148 [Source:HGNC Symbol;Acc:HGNC:12933]
Entrez Summary The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]
Ensembl ID: ENSG00000163848
External Link: CisBP
Interpro IPR007087; IPR015880;
Protein Domain: ENSP00000353863
Protein Domain: ENSP00000420102
Protein Domain: ENSP00000420335
Protein Domain: ENSP00000420448
Protein Domain: ENSP00000419322
Domain:
Protein: ENSP00000353863DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000420102DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000420335DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000420448DBD: C2H2 ZF Containing ProteinsOther:
Protein: ENSP00000419322DBD: C2H2 ZF Containing ProteinsOther:

Previous Annotations

Source Annotation
TF-CAT classification TF Gene_DNA-Binding
sequence-specific_DNA Binding_
PMIDS:8355710
Vaquerizas 2009 TF classification
"a" Has direct evidence of TF function;
"b" Has evidence for an orthologous TF;
"c" contains likely DBDs, but has no functional evidence;
"x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription;
"other" category contains proteins without clear DBDs they curated from external sources.
a
CisBP considers it as a TF? Yes
TFclass considers it as a TF? Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" Yes
GO-Info GO:0001078
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a
IDA - PMID:12771217
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding;
1a2 There is high confidence data for a close ortholog (as defined in CisBP);
2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model;
2a2 There is lower confidence evidence for an close ortholog;
3a There is decent circumstantial evidence for its role as a TF or not;
4a Two or more datasets predict it as a TF;
5a One of the source datasets predicts is as a TF
2a1, Lower confidence direct evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source Annotation Motif Evidence
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
TransfacTransfacLicense requiredDirect
MiscHocoMocoDirect
PBMBadis09Inferred - Zfp281 (71% AA Identity, Mus musculus)
HT-SELEXYin2017Inferred - ZNF281 (71% AA Identity, Homo sapiens)
Methyl-HT-SELEXYin2017Inferred - ZNF281 (71% AA Identity, Homo sapiens)
ChIP-seqhmCHIPInferred - Zfp281 (71% AA Identity, Mus musculus)
TransfacTransfacLicense requiredInferred - Zfp281 (71% AA Identity, Mus musculus)

Structure

Structure PDB Not_Covered

Experimental History

Method Constructs
Tried in PBM?
(Whether the protein was tried in PBM or not)
Tried in HT-SELEX
(Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information?
(Tried with another method and failed?)

External Contribution