Assessment | Binding Mode | Motif Status | Notes | Comments |
---|---|---|---|---|
Known motif | 1 Monomer or homomultimer | 100 perc ID - in vitro |
Description: | NK6 homeobox 1 [Source:HGNC Symbol;Acc:HGNC:7839] | ||||||
Entrez Summary | #!usr/local/bin/perl ?> In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008] | ||||||
Ensembl ID: | ENSG00000163623 | ||||||
External Link: | CisBP | ||||||
Interpro | IPR000047; IPR001356; IPR009057; IPR017970; IPR020479; ; | ||||||
Protein Domain: | ENSP00000295886 | ||||||
Protein Domain: | ENSP00000449761 | ||||||
Domain: |
|
Source | Annotation |
TF-CAT classification |
TF Gene_DNA-Binding sequence-specific_DNA Binding_ PMIDS:15883383 |
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources. |
a |
CisBP considers it as a TF? | Yes |
TFclass considers it as a TF? | Yes |
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding" | Yes |
GO-Info |
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a IEA - GO_REF:0000019 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity ISS - GO_REF:0000024 |
Initial Assessment
1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF |
1a1, Direct HQ evidence |
TF has conditional DNA-binding requirements |