The Human Transcription Factors

Conclusion

Assessment	Binding Mode	Motif Status	Notes	Comments
Known motif	1 Monomer or homomultimer	High-throughput in vitro

Description

Description:

FEV, ETS transcription factor [Source:HGNC Symbol;Acc:HGNC:18562]

Entrez Summary

This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]

Ensembl ID:

ENSG00000163497

External Link:

CisBP

Interpro

IPR000418; ;

Protein Domain:

ENSP00000295727

Domain:

Protein: ENSP00000295727	DBD: ETS	Other:

Previous Annotations

Source	Annotation
TF-CAT classification	TF Gene_DNA-Binding sequence-specific_DNA Binding Transactivation_ PMIDS:9468386
Vaquerizas 2009 TF classification "a" Has direct evidence of TF function; "b" Has evidence for an orthologous TF; "c" contains likely DBDs, but has no functional evidence; "x" is an unlikely TF such as predicted gene, genes with likely non-specific DBDs or that have function outside transcription; "other" category contains proteins without clear DBDs they curated from external sources.	a
CisBP considers it as a TF?	Yes
TFclass considers it as a TF?	Yes
Has GO:0003700 "transcription factor activity, sequence-specific DNA binding"	Yes
GO-Info	GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA - GO_REF:0000033 GO:0003700 sequence-specific DNA binding transcription factor activity TAS - PMID:9121764
Initial Assessment 1a1 Protein has a high confidence PWM (HT-SELEX, PBM or B1H model) or there is a crystal structure that supports sequence specific DNA binding; 1a2 There is high confidence data for a close ortholog (as defined in CisBP); 2a1 There is lower confidence direct evidence, such as a Jaspar, Hocomoco or Transfac model; 2a2 There is lower confidence evidence for an close ortholog; 3a There is decent circumstantial evidence for its role as a TF or not; 4a Two or more datasets predict it as a TF; 5a One of the source datasets predicts is as a TF	1a1, Direct HQ evidence
TF has conditional DNA-binding requirements

DNA-Binding

Published Motif Data

Source	Annotation	Motif	Evidence
HT-SELEX	Jolma2013		Direct
HT-SELEX	Yin2017		Direct
Methyl-HT-SELEX	Yin2017		Direct
Misc	HocoMoco		Direct
HT-SELEX	Nitta2015		Inferred - Ets65A (88% AA Identity, Drosophila melanogaster)
SMiLE-seq	Isakova2017		Inferred - FLI1 (88% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (88% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (88% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (88% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - FLI1 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (88% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - FLI1 (88% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Fli1 (88% AA Identity, Mus musculus)
SELEX	JASPAR		Inferred - FLI1 (88% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - FLI1 (88% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - FLI1 (88% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - FLI1 (88% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - Fli1 (88% AA Identity, Mus musculus)
HT-SELEX	Jolma2010		Inferred - ERG (86% AA Identity, Homo sapiens)
HT-SELEX	Jolma2010		Inferred - ERG (86% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (86% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (86% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (86% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ERG (86% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (86% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (86% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (86% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ERG (86% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Erg (86% AA Identity, Mus musculus)
SELEX	JASPAR		Inferred - ERG (86% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ERG (86% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ERG (86% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ERG (86% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ERG (86% AA Identity, Homo sapiens)
HT-SELEX	Nitta2015		Inferred - Ets21C (85% AA Identity, Drosophila melanogaster)
PBM	Zoo_01		Inferred - Ets21C (85% AA Identity, Drosophila melanogaster)
HT-SELEX	Nitta2015		Inferred - pnt (65% AA Identity, Drosophila melanogaster)
PBM	Wei10		Inferred - Ets1 (64% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - ETS1B_CHICK (64% AA Identity, Gallus gallus)
HT-SELEX	Yin2017		Inferred - ETV5 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV5 (59% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV5 (59% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv5 (59% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - ETV5 (59% AA Identity, Homo sapiens)
HT-SELEX	Nitta2015		Inferred - Ets96B (57% AA Identity, Drosophila melanogaster)
HT-SELEX	Yin2017		Inferred - ETV1 (57% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV1 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV1 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV1 (57% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv1 (57% AA Identity, Mus musculus)
PBM	Wei10		Inferred - Etv1 (57% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - ETV4 (57% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV4 (57% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV4 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (57% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV4 (57% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv4 (57% AA Identity, Mus musculus)
Transfac	Transfac	License required	Inferred - ETV4 (57% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETV4 (57% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ETV1 (57% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ETV4 (57% AA Identity, Homo sapiens)
PBM	Zoo_01		Inferred - elk4 (56% AA Identity, Tetraodon nigroviridis)
SMiLE-seq	Isakova2017		Inferred - GABPA (55% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - GABPA (55% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - GABPA (55% AA Identity, Homo sapiens)
PBM	Badis09		Inferred - Gabpa (55% AA Identity, Mus musculus)
PBM	Wei10		Inferred - Gabpa (55% AA Identity, Mus musculus)
ChIP-seq	ENCODE		Inferred - GABPA (55% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (55% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (55% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (55% AA Identity, Homo sapiens)
ChIP-seq	ENCODE		Inferred - GABPA (55% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (55% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (55% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (55% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (55% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (55% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - GABPA (55% AA Identity, Homo sapiens)
ChIP-seq	JASPAR		Inferred - Gabpa (55% AA Identity, Mus musculus)
Misc	HocoMoco		Inferred - GABPA (55% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - GABPA (55% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK1 (54% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ELK1 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK1 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ELK1 (54% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Elk1 (54% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - ETV2 (54% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV2 (54% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - XP_911724.4 (54% AA Identity, Mus musculus)
SELEX	JASPAR		Inferred - ELK1 (54% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (54% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (54% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (54% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (54% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ELK1 (54% AA Identity, Homo sapiens)
Transfac	Transfac	License required	Inferred - ETV2 (54% AA Identity, Homo sapiens)
Misc	HocoMoco		Inferred - ELK1 (54% AA Identity, Homo sapiens)
Misc	HOMER		Inferred - ELK1 (54% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Elk4 (53% AA Identity, Mus musculus)
HT-SELEX	Yin2017		Inferred - ETV3 (53% AA Identity, Homo sapiens)
HT-SELEX	Yin2017		Inferred - ETV3 (53% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV3 (53% AA Identity, Homo sapiens)
Methyl-HT-SELEX	Yin2017		Inferred - ETV3 (53% AA Identity, Homo sapiens)
PBM	Wei10		Inferred - Etv3 (53% AA Identity, Mus musculus)

Structure

Structure	PDB	3ZP5

Experimental History

Method	Constructs
Tried in PBM? (Whether the protein was tried in PBM or not)
Tried in HT-SELEX (Whether the protein was tried in HT-SELEX or not, and if so, then what kind of clones were tested)
Other Information? (Tried with another method and failed?)

External Contribution

Name
Email
Comment
Reference

TF Info Page for FEV (Ets)